Figure 2.
Regional plots of sentinel SNPs from conditional analysis associated with CIN3 and invasive cervical cancer in PAX8 (chromosome 2; A), CLPTM1L (chromosome 5; B), and HLA (chromosome 6; C and D)
The p value of the association between variant and the cervical cancer status is represented by the log10 scale (y-axis) in function of the genetic location. SNPs are colour coded in relation to their correlation (as measured by their recombination rate [r2]) with the sentinel SNP (shown in red) in the region. In the lower panel of each plot, gene annotations are provided according to the 1000 Genomes project 2014. SNP=single nucleotide polymorphism. CIN3=cervical intraepithelial neoplasia grade 3.