Figure 3.

Mendelian randomisation analysis of exposures associated with CIN3 and invasive cervical cancer

(A) Forest plot shows inverse variance weighted mendelian randomisation for all identified known environmental risk or protective factors for cervical cancer with available GWAS, to determine effect sizes by OR and 95% CI (x-axis; n=3). (B) Three mendelian randomisation exposures (x-axis, lifetime smoking index; number of sexual partners; age of first pregnancy) found to have a significant association with cervical cancer (y-axis). Each blue point represents a genetic variant used as an instrumental variable in the mendelian randomisation analysis and error bars show standard errors of genetic associations. The dark blue trendline represents the causal effect estimate from the inverse variance weighting mendelian randomisation on the β scale. CIN3=cervical intraepithelial neoplasia grade 3. GWAS=genome-wide association study. OR=odds ratio.