Figure 1.

A general scheme illustrating the potential mechanistic pathway of Notch signaling in the pathogenesis of pulmonary fibrosis. The current study demonstrates that Notch3 is upregulated in fibroblasts and promotes myofibroblast transformation and survival, which is involved in excessive collagen deposition in the lung parenchyma. Black arrows highlight positive regulation. Perpendicular line highlights negative regulation. Dll = Delta-like ligand; Jag = Jagged ligand; Maml = mastermind-like protein; NICD = the intracellular domain of the Notch protein; ON = transcriptional activation; P300 = histone acetyltransferase p300; Rbp = recombination signal binding protein.