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Key pathways in progression of lung injury. AFC = alveolar fluid clearance; ANG-2 = angiopoietin-2; CRP = C-reactive protein; IBA = inhaled β-agonist; ICS = inhaled corticosteroid; IL-6 = interleukin 6; IL-8 = interleukin 8; RAGE = receptor for advanced glycation end products; SP-D = surfactant protein D; TNF-α = tumor necrosis factor-α.
