Table 2.

Optimization for arene deoxyradiofluorination

entry	deviation from standard conditions	RCY (%)
1	none	94.6 ± 0.4 (n=3)
2	w/o TBAHCO3	75.2
3	w/o TBAHCO3, + H2O (100 μL)	N.D.
4	S2 (0.01 mmol), w/o TBAHCO3	71.7
5	S2 (0.002 mmol), w/o TBAHCO3	34.3
6	S2 (0.01 mmol), 1 (0.3 mg), w/o TBAHCO3	24.3
7	blue LEDs	83.2
8	No photocatalyst	N.D.b
9	No irradiation	2.6

All radiochemical yields (RCYs) are calculated by HPLC isolation starting from azeotropically dried [¹⁸F]TBAF, and represent one experiment unless otherwise noted;

^*See Supplementary Tables 2–7 for full optimization details.