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. Author manuscript; available in PMC: 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5;356(6337):eaaj2239. doi: 10.1126/science.aaj2239

Fig. 2. Similarity of motifs.

Fig. 2.

The dendrogram indicates similarities between the motifs from HT-SELEX (thin dendrogram lines) and methyl-SELEX (thick green bars at the end of dendrogram lines). Barcode logos (25) for each factor are also shown. The center of the dendrogram shows an example of the conversion of a sequence logo into a barcode logo (top) and the color key for the TF families (bottom). Motifs for TFs in the same structural families are generally similar to each other, and motifs from methyl-SELEX and HT-SELEX are also closely related in most cases (green and black ends are found in the same branches). This is because many TFs do not have CpGs in their motifs, and the changes induced by methylation generally only affect one dinucleotide in a motif. Homeo., homeodomain; zin. fin., zinc finger; nuc. rec., nuclear receptor.