Table 4.

Binding free energy of proposed TMPRSS2 inhibitors

Molecule	Energy (Kcal/mol)			Standard error of ∆Gbind
	aElec	bvdW	∆Gbind
A1	− 37.317	− 43.564	− 36.546	4.726
A2	− 19.191	− 51.521	− 42.252	3.370
A3	− 18.494	− 45.633	− 36.534	2.617
A4	− 25.883	− 35.702	− 30.462	3.079
A5	− 25.566	− 50.009	− 42.916	3.845

^aElectrostatic

^bven der Waal’s