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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Nat Aging. 2021 Jan 14;1(1):73–86. doi: 10.1038/s43587-020-00006-2

Figure 1: Branched-chain amino acid restriction extends the lifespan of progeroid mice.

Figure 1:

(A-B) Kaplan-Meier plots of the survival of Lmna−/− (A) females (N; Control = 9, Low BCAA = 18, Low AA = 13 biologically independent animals) and (B) males fed the indicated diets starting at weaning (N; Control = 20, Low BCAA = 14, Low AA = 10 biologically independent animals), see also Tables S2 and S3. (C) Echocardiography data of anterior and posterior left ventricular wall thickness (mm) in systole, and fractional shortening (%) in female wild-type and Lmna−/− mice fed the indicated diets from weaning to 40-55 days of age; full echocardiography data can be found in Table S4 (N; WT and Lmna−/− Control = 4, Low BCAA = 3, Low AA = 7 biologically independent animals; two-sided Dunnett’s test in comparison to Lmna−/− Control values post one-way ANOVA; LVAWs *p = 0.0224, LVPWs *p = 0.0406, FS #p = 0.0724). (D) Kaplan-Meier plot of the survival of LmnaG609G/G609G mice fed the indicated diets starting at weaning (N; Control = 15, Low BCAA = 12, Low AA = 8 biologically independent animals, Tables S3 and S5). Data are represented as mean ± SEM.