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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Nat Aging. 2021 Jan 14;1(1):73–86. doi: 10.1038/s43587-020-00006-2

Figure 4: A Low BCAA diet does not extend the lifespan of middle-aged mice.

Figure 4:

(A-B) Kaplan-Meier plots showing the survival of (A) female (N = 34 biologically independent animals for both groups) and (B) male C57BL/6J.Nia mice fed the indicated diets starting at 16 months of age (N = 35 biologically independent animals for both groups) see also Table S8. (C) Percent of female mice with and without cancer observed at necropsy from lifespan in (A) (N; Control cancer = 17, Low BCAA cancer = 8, Control non-cancer = 8, Low BCAA non-cancer = 17 biologically independent animals). (D) Percent of males with and without cancer observed at necropsy from lifespan in (B) (N; Control cancer = 10, Low BCAA cancer = 9, Control non-cancer = 15, Low BCAA non-cancer = 16 biologically independent animals). (C-D) two-sided Fisher’s exact test, * p = 0.0254.