Table 2.

Fold changes in lipopolysaccharide (LPS) versus control group (Con) and fisetin (FIS)+LPS versus LPS for the macroautophagy molecular markers according to microarray analysis

Associated process	Gene name	Protein name	Fold change
			LPS versus Con	FIS+LPS versus LPS
The Unc-51-like kinase (ULK) complex	ULK1	Serine/threonine-protein kinase ULK1	0.57	1.64
	ULK2	Serine/threonine-protein kinase ULK2	1.04	0.90
	ATG13	Autophagy-related protein 13	1.15	0.76
	Rb1cc1	RB1-inducible coiled-coil protein 1	1.42	0.90
The PI3K complex	BECN1	Beclin-1	1.21	1.20
	ATG14	Beclin 1-associated autophagy-related key regulator	0.67	1.75
ATG8/LC3 conjugation system	Map1lc3b	Microtubule-associated proteins 1A/1B light chain 3B	0.69	1.45
	Map1lc3a	Microtubule-associated proteins 1A/1B light chain 3A	1.28	0.95
	Gabarap	Gamma-aminobutyric acid receptor-associated protein	1.08	0.93
	Gabarapl1	Gamma-aminobutyric acid receptor-associated protein-like 1	1.43	1.23
	Gabarapl2	Gamma-aminobutyric acid receptor-associated protein-like 2	1.15	0.98
	Atg4b	Cysteine protease ATG4B	1.16	0.95
	Atg4a	Cysteine protease ATG4A	1.14	0.78
	Atg4d	Cysteine protease ATG4D	1.01	1.10
	Atg7	Ubiquitin-like modifier-activating enzyme ATG7	1.12	0.75
	Atg3	Ubiquitin-like-conjugating enzyme ATG3	1.74	1.16
ATG12 conjugation system	Atg12	Ubiquitin-like protein ATG12	1.16	1.64
	Atg7	Ubiquitin-like modifier-activating enzyme ATG7	1.12	0.75
	Atg10	Ubiquitin-like-conjugating enzyme ATG10	0.51	1.09
	Atg5	Autophagy protein 5	0.90	1.00
	Atg16l1	Autophagy-related protein 16-1	1.12	1.39
Lysosome	LAMP1	Lysosome-associated membrane glycoprotein 1	0.95	1.11
	LAMP2	Lysosome-associated membrane glycoprotein 2	1.14	1.08
Autophagy substrates	SQSTM1	Ubiquitin-binding protein p62	5.06	0.85