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. 2021 Mar 26;4(2):898–907. doi: 10.1021/acsptsci.1c00022

Figure 3.

Figure 3

Inhibition of the ATPase activity of SARS-CoV-2 nsp13 by disufiram and ebselen. The ATPase activity of SARS-CoV-2 nsp13 (0.25 μM) was estimated by measurement of the phosphate ion concentrations using the molybdenum blue method in the presence of 0.25 μM ssDNA and different concentrations of disulfiram (0.2–12.5 μM) or ebselen (0.02–10.0 μM). The half-maximal inhibitory activity (IC50) of disufiram and ebselen in inhibiting the ATPase activity of SARS-CoV-2 nsp13 is shown. Error bars shown in the two panels represent the standard errors from three replicates of the experiment.