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. 2021 Mar 26;4(2):898–907. doi: 10.1021/acsptsci.1c00022

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© 2021 American Chemical Society

This article is made available via the ACS COVID-19 subset for unrestricted RESEARCH re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Antiviral potential of disulfiram/ebselen and remdesivir. (A) The active form of remdesivir inhibits nsp12 RdRp by competing with the natural ATP substrate. Disulfiram/ebselen can inhibit nsp14 ExoN proofreading activity, as shown above. The SARS-CoV-2 infection rates in Vero E6 cells treated with remdesivir and (B) disulfiram or (C) ebselen were determined and are shown as means and standard deviations (n = 4). The infection rate of no-compound treatment was set as 100%. The p values were calculated by t-test.