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. 2021 Mar 28;13(1):1902719. doi: 10.1080/19490976.2021.1902719

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Ferroptosis is present in and enhances intestinal ischemia/reperfusion (I/R) injury in mice. (a-b) The total glutathione (GSH) and GSH/GSSG levels in the intestinal tissue. (c-d) Malondialdehyde (MDA) and Fe²⁺ levels in the intestinal tissue. (e) The protein levels of glutathione peroxidase 4 (Gpx4), ferritin heavy chain 1 (Fth1) and cyclooxygenase 2 (Cox-2), scale bar is 100 μm. (f-h) Relative quantitative statistics of Gpx4, Fth1 and Cox-2 protein expression. (i) 7-day survival rate of mice after intestinal I/R, n = 20. (j) Chiu’s pathology score. (k) Hematoxylin-eosin (HE) staining of small intestine tissue and the relative protein levels of the intestinal barrier tight junction Occludin and zona occludens (ZO)-1, scale bar is 100 μm. (l-m) Relative fluorescence quantitative statistics of Occludin and ZO-1 protein expression. The results are expressed as the mean ± SEM. n = 8. * p < .05, ** p < .01, *** p < .001 by one-way ANOVA (Tukey’s test)