Table 1.
Completed and Ongoing Clinical Trials on Whole-Lung LDRT for COVID-19 Registered in the ClinicalTrials.gov
| Title of the Trial | Status | Conditions | Locations | Interventions | Estimated Enrollment | ClinicalTrials.gov Id |
|---|---|---|---|---|---|---|
| Low Dose Whole Lung Radiotherapy for Older Patients With COVID-19 Pneumonitis | NYR | Covid-19 Pneumonitis | International Geriatric Radiotherapy Group, Institute of Radiation Oncology, Cantonal Hospital Graubuenden, Chur, Switzerland | Radiation: Whole lung LDRT for older patients with COVID-19 pneumonitis | 500 | NCT04493294 |
| Radiation Eliminates Storming Cytokines and Unchecked Edema as 1-Day Treatment for COVID-19 (RESCUE 1–19) | R | Pneumonia| COVID19 |SARS Pneumonia | Emory University Hospital, Winship Cancer Institute, Atlanta, GA, USA | Radiation: LDRT | 10 | NCT04366791 |
| COVID-19 Pneumonitis Low Dose Lung RT (COLOR-19) | R | COVID-19 | ASST SpedaliCivili, Brescia, Italy | Radiation: Single fraction whole lung RT | 30 | NCT04377477 |
| Low Dose Anti-inflammatory RT for the Treatment of Pneumonia by COVID-19 | R | Pneumonia, Viral | Hospital Sant Joan de Reus, Reus, Tarragona, Spain | Radiation: LDRT| Drug: Hydroxychloroquine Sulfate| Drug: Ritonavir/lopinavir| Drug: Tocilizumab Injection [Actemra]| Drug: Azithromycin| Drug: Corticosteroid| Drug: Low molecular weight heparin| Device: Oxygen supply | 106 | NCT04380818 |
| LDRT in COVID-19 Pneumonia | R | COVID| SARS | Imam Hossein Hospital, Tehran, Iran | Radiation: LDRT | 5 | NCT04390412 |
| Lung Irradiation for COVID-19 Pneumonia | R | SARS-CoV 2 | Brigham and Women’s Hospital, Boston, MA, USA | Radiation: Phase 1| Radiation: Phase 2 | 48 | NCT04393948 |
| Ultra-Low Doses of Therapy with Radiation Applicated to COVID-19 | R | Pneumonia, Viral| Cytokine Storm | Hospital La Milagrosa, GenesisCare, Madrid, Spain | Radiation: Ultra-Low-dose RT| Device: ventilatory support with oxygen therapy| Drug: Lopinavir/ritonavir| Drug: Hydroxychloroquine| Drug: Azithromycin| Drug: Piperacillin/tazobactam| Drug: Low molecular weight heparin| Drug: Corticosteroid injection| Drug: Tocilizumab | 15 | NCT04394182 |
| LDRT for COVID-19 Pneumonia: A Pilot Study | R | COVID-19| Pneumonia | All India Institute of Medical Sciences, New Delhi, India | Radiation: LDRT | 10 | NCT04394793 |
| Low Dose Pulmonary Irradiation in Patients With COVID-19 Infection of Bad Prognosis | NYR | COVID| Pneumonia, Viral | Hospital Provincial de Castellon, Castellón De La Plana, Castellon, Spain | Radiation: Lung LDRT | 41 | NCT04414293 |
| LDRT for COVID-19 Pneumonitis | R | COVID-19 | Servicio de Oncología Radioterápica. Hospital Clínico San Carlos, Madrid, Spain | Radiation: RT | 41 | NCT04420390 |
| Low Dose Whole Lung RT for Patients With COVID-19 and Respiratory Compromise | R | COVID-19 | Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus, Ohio, USA | Radiation: RT | 24 | NCT04427566 |
| Best Supportive Care with or without Low Dose Whole Lung RT for the Treatment of COVID-19 | R | Pneumonia| Severe Acute Respiratory Syndrome| Symptomatic COVID-19 Infection Laboratory-Confirmed | Emory University Hospital, Winship Cancer Institute, Atlanta, GA, USA | Other: Best Practice| Radiation: LDRT | 52 | NCT04433949 |
| LDRT For Patients With SARS-COV-2 (COVID-19) Pneumonia | NYR | Covid-19| Sars-CoV2| Pneumonia | Ohio State University Medical Center, Columbus, Ohio, USA | Radiation: Low dose radiation 35 cGy| Radiation: High dose radiation 100 cGy | 100 | NCT04466683 |
Abbreviations: R, recruiting; NYR, not yet recruiting