| • Peripheral blood mononuclear cells (PBMC) – flow cytometry, CyTOF® |
| • Plasma – cytokines, miRNA, exosomes, proteins/metabolites, neutralizing antibodies, hypoxia markers |
| ○ Radiation pneumonitis markers (TGF-β, KL-6, surfactants, IL-1ra, IL-6, sTNF, C3, C4b-binding protein-α) |
| ○ Endothelial/cardiac injury markers (hscTnT, CKMB, NT-proBNP, ANP) |
| ○ Systemic inflammation markers (CRP, LDH, ferritin, D-dimer, IL-6) |
| • Bronchial secretions (BAL fluid) – viral load, flow cytometry |
| • Pulmonary function tests, oxygen requirements, ventilator settings, radiographic imaging, dosimetry |
| • Stool – viral load |
| • Co-morbidities – concurrent medications, prior treatments, quality-of-life |
