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. 2020 Sep 18;36(Suppl 1):S180–S195. doi: 10.3904/kjim.2019.413

Figure 3.

Figure 3.

Representative photomicrographs of transmission electron microscopy illustrating the characteristics of renal injury in unilateral ureteral obstruction (UUO) with or without L-carnitine (LC) treatment and quantificative analyses of mitochondrial number and size. (A) Tubular basement membrane thickening (arrow) and interstitial collagen deposition; (B) tubular vacuolization and atrophy; (C) collagen fibers within tubulointerstitium (starlikes); (D) swelling of the tubular epithelium and interstitium, with massive inflammatory cell infiltration (circle); (E) apoptotic bodies (arrow); (F) myelin body (arrow); (G) autophagosome (arrows); (H) mitochondrial fission; (I) mitochondrial fussion; (J) mild tubular basement membrane thickening after LC treatment; (K) improved collagen deposition within the tubulointerstitium by LC; (L) LC treatment decreases the UUO-induced inflammatory cells infiltration within the tubulointerstitium. (M) Quantitative analyses of mitochondrial area and the number of mitochondria. ap < 0.01 vs. sham, bp < 0.05 vs. UUO, cp < 0.05 vs. UUO14.