Table 4.

Multivariate analysis of variables affecting the overall survival in the very elderly patients with colorectal cancer (n = 101)

Variable	Overall survival
	HR (95% CI)	p value
BMI >25 kg/m2	0.433 (0.232–0.807)	0.008
PS 0–1	0.269 (0.153–0.472)	0.000
Localized stage	0.183 (0.097–0.347)	0.000
WD/MD	0.305 (0.291–1.471)	0.305
SIRT1 high	1.856 (1.101–3.129)	0.020
SIRT2 high	0.655 (0.385–1.116)	0.120

HR, hazard ratio; CI, confidence interval; BMI, body mass index; PS, performance status; WD, well-differentiated; MD, moderately differentiated; PD, poorly differentiated; SIRT1, sirtuin 1; SIRT2, sirtuin 2.