Table 1.
Demographic data and data related to serum concentrations of ARI and DARI in different groups
| Characteristic | ARI group (n=113) |
Comedication group (n=186) |
χ2 | P value | Comedication subgroup (n=186) |
χ2 | P value | |||
| CLZ (n=61) | RIP (n=36) | QTP (n=40) | OLZ (n=49) | |||||||
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | |||||
| Demographic | ||||||||||
| Sex | ||||||||||
| Men | 43 (38.1) | 63 (33.9) | 0.03 | 0.87 | 31 (50.8) | 7 (19.4) | 8 (20.0) | 17 (34.7) | 60.04 | <0.001 |
| Women | 70 (61.9) | 123 (66.1) | 30 (49.2) | 29 (80.6) | 32 (80.0) | 32 (65.3) | ||||
| Age, years | Mean (SD) | Mean (SD) | t | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | F | ||
| 45.2 (17.2) | 42.8 (14.2) | 1.99 | 0.05 | 48.5 (13.5) | 33.1 (10.9) | 42.7 (12.6) | 39.0 (14.2) | 15.68 | <0.001 | |
| Data related to serum concentration | ||||||||||
| ARI dose, mg/d | 20.0 (9.3) | 21.9 (10.0) | −2.63 | 0.009 | 20.1 (7.8) | 22.9 (16.0) | 24.2 (10.0) | 21.7 (8.6) | 5.18 | <0.001 |
| Comedication dose, mg/d | Median (IQR 25–75) | Median (IQR 25–75) | χ2 | Median (IQR 25–75) | Median (IQR 25–75) | Median (IQR 25–75) | Median (IQR 25–75) | χ2 | ||
| 100.0 (87.0–140.0) | 2.0 (1.5–2.5) | 250.0 (200.0–300.0) | 10.0 (7.5–12.5) | |||||||
| ARI concentration, ng/ml |
221.6 (130.1–376.1) | 216.8 (131.3–328.7) | −1.42 | 0.16 | 206.6 (131.2–316.7) | 207.8 (115.4–364.6) | 218.2 (126.3–305.2) | 238.7 (134.8–349.6) | 3.17 | 0.53 |
| DARI concentration, ng/ml |
95.4 (56.1–166.1) | 108.0 (64.1–168.5) | −1.71 | 0.09 | 108.5 (72.7–154.3) | 87.9 (50.8–164.4) | 105.9 (54.8–186.6) | 109.3 (65.8–173.9) | 6.08 | 0.19 |
| ARI+DARI concentration, ng/ml |
337.2 (198.0–530.3) | 331.3 (210.0–499.0) | −0.64 | 0.52 | 324.4 (224.7–462.9) | 284.4 (181.3–520.8) | 317.5 (208.9–483.3) | 367.9 (211.1–505.0) | 1.56 | 0.82 |
| ARI concentration/ARI dose, d/L |
12.2 (7.4–19.7) | 10.5 (6.7–15.2) | −3.21 | 0.001 | 10.8 (7.4–15.8) | 10.6 (4.4–19.5) | 9.4 (7.2–11.8) | 11.6 (6.6–17.6) | 18.24 | 0.001 |
| DARI concentration/ARI dose, d/L | 5.3 (2.9–8.7) | 5.3 (3.3–7.7) | −0.14 | 0.89 | 5.8 (3.9–8.5) | 4.2 (2.4–7.9) | 4.9 (3.2–6.7) | 5.3 (3.3–8.4) | 10.65 | 0.03 |
| ARI+DARI concentration/ARI dose, d/L | 17.5 (10.8–28.4) | 15.7 (11.0–22.8) | −2.50 | 0.01 | 17.4 (12.2–23.1) | 15.0 (7.4–27.2) | 14.2 (10.9–18.2) | 16.3 (10.6–25.2) | 15.38 | 0.004 |
ARI, aripiprazole; CLZ, clozapine; DARI, dehydroaripiprazole; IQR, interquartile range; OLZ, olanzapine; QTP, quetiapine; RIP, risperidone; SD, standard deviation.