Table 2.
Demographic data and data related to serum concentration of ARI and DARI in men in different groups
| Characteristic | ARI group (n=43) |
Comedication group (n=63) |
χ2 | P value | Comedication group (n=63) |
|||||
| CLZ (n=31) | RIP (n=7) | QTP (n=8) | OLZ (n=17) | χ2 | P value | |||||
| Demographic | ||||||||||
| Age, years | Mean (SD) | Mean (SD) | t | P value | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | F | P value |
| 36.1 (10.4) | 42.3 (12.6) | −4.23 | <0.001 | 45.6 (11.2) | 29.8 (12.0) | 34.6 (15.8) | 41.5 (12.0) | 10.78 | <0.001 | |
| Data related to serum concentration | ||||||||||
| ARI dose, mg/d | 21.4 (7.2) | 20.5 (7.1) | 0.93 | 0.36 | 19.9 (5.5) | 25.9 (12.8) | 20.0 (3.8) | 20.4 (8.0) | 1.96 | 0.10 |
| Comedication dose, mg/d | median (IQR 25–75) |
median (IQR 25–75) |
χ2 | P value | median (IQR 25–75) |
median (IQR 25–75) |
median (IQR 25–75) |
median (IQR 25–75) |
χ2 | P value |
| 113.0 (100.0–163.0) | 2.0 (2.0–3.0) | 200.0 (150.0–300.0) | 10.0 (7.5–10.0) | |||||||
| ARI concentration, ng/ml | 233.6 (134.3–339.5) | 237.9 (140.6–316.5) | 0.15 | 0.70 | 245.7 (166.6–322.4) | 260.9 (126.1–324.5) | 166.1 (124.4–303.8) | 237.0 (137.4–304.6) | 1.34 | 0.86 |
| DARI concentration, ng/ml | 94.1 (47.5–176.5) | 110.5 (65.6–151.9) | 2.24 | 0.14 | 115.3 (80.4–163.5) | 89.7 (36.1–171.0) | 100.4 (62.0–139.4) | 104.3 (65.0–130.7) | 6.57 | 0.16 |
| ARI+DARI concentration, ng/ml | 331.5 (199.2–516.8) | 336.1 (227.0–465.7) | 0.02 | 0.90 | 378.6 (264.5–488.7) | 384.1 (184.0–544.2) | 265.0 (211.1–443.2) | 352.4 (210.1–471.9) | 2.48 | 0.65 |
| ARI concentration/ARI dose, d/L | 12.0 (7.6–16.1) | 11.8 (8.2–15.3) | 0.03 | 0.86 | 12.3 (8.6–15.4) | 10.2 (4.4–17.1) | 8.5 (5.4–16.2) | 11.8 (8.0–14.9) | 1.23 | 0.87 |
| DARI concentration/ARI dose, d/L | 4.8 (2.5–8.3) | 5.5 (3.7–7.8) | 2.45 | 0.12 | 6.8 (4.4–8.2) | 2.3 (1.8–7.8) | 5.0 (3.1–8.0) | 5.1 (3.4–6.3) | 9.41 | 0.05 |
| ARI+DARI concentration/ARI dose, d/L | 16.9 (10.7–24.2) | 18.1 (11.9–23.1) | 0.15 | 0.70 | 19.6 (12.9–23.2) | 20.8 (6.0–27.2) | 13.3 (10.5–23.7) | 16.4 (11.6–22.2) | 2.68 | 0.61 |
ARI, aripiprazole; CLZ, clozapine; DARI, dehydroaripiprazole; IQR, interquartile range; OLZ, olanzapine; QTP, quetiapine; RIP, risperidone; SD, standard deviation.