Table 3.
Demographic data and data related to serum concentration of ARI and DARI in women in different groups
| Characteristic | ARI group (n=70) |
Comedication group (n=123） |
χ2 | P value | Comedication group (n=123) |
χ2 | P value | |||
| CLZ (n=30) | RIP (n=29) | QTP (n=32) | OLZ (n=32) | |||||||
| Demographic | ||||||||||
| Age, years | Mean (SD) | Mean (SD) | t | P value | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | F | P value |
| 49.7 (18.5) | 43.0 (14.8) | 4.30 | <0.001 | 51.1 (14.9) | 33.9 (10.6) | 43.4 (12.1) | 37.1 (15.5) | 18.54 | <0.001 | |
| Data related to serum concentration | ||||||||||
| ARI dose, mg/d | 19.3 (10.1) | 22.6 (11.0) | –3.43 | 0.001 | 20.3 (9.4) | 22.2 (16.7) | 24.5 (10.3) | 22.7 (9.0) | 4.95 | 0.001 |
| Comedication dose, mg/d | Median (IQR 25–75) |
Median (IQR 25–75) |
χ2 | P value | Median (IQR25–IQR75) |
Median (IQR25–IQR75) |
Median (IQR25–IQR75) |
Median (IQR25–IQR75) |
χ2 | P value |
| 90.0 (87.0–100.0) | 2.0 (1.5–2.5) | 250.0 (200.0–300.0) | 10.0 (8.1–12.5) | |||||||
| ARI concentration, ng/ml | 210.1 (127.9–386.1) | 207.6 (121.2–340.5) | −1.40 | 0.16 | 200.5 (119.5–314.6) | 195.3 (110.8–380.3) | 218.6 (129.3–310.9) | 240.9 (125.3–392.4) | 4.76 | 0.31 |
| DARI concentration, ng/ml | 96.7 (58.1–165.0) | 101.0 (69.1–177.2) | −1.06 | 0.29 | 99.3 (68.2–146.6) | 86.1 (51.3–162.3) | 111.4 (52.6–190.5) | 112.7 (65.8–198.3) | 4.04 | 0.40 |
| ARI+DARI concentration, ng/ml | 337.2 (198.0–534.2) | 327.9 (199.5–512.0) | −0.77 | 0.44 | 302.8 (207.3–450.2) | 272.9 (170.7–518.0) | 334.7 (206.3–514.8) | 386.8 (214.0–557.7) | 3.61 | 0.46 |
| ARI concentration/ARI dose, d/L | 12.7 (7.3–22.5) | 9.7 (6.2–15.1) | −3.59 | <0.001 | 10.1 (6.4–17.0) | 10.9 (4.2–20.4) | 9.5 (7.2–11.8) | 10.7 (5.5–19.8) | 15.91 | 0.003 |
| DARI concentration/ARI dose, d/L | 5.6 (3.5–9.0) | 5.1 (3.3–7.7) | −1.27 | 0.20 | 5.2 (3.6–8.6) | 4.8 (2.9–8.1) | 4.9 (3.2–6.5) | 5.3 (3.3–9.4) | 6.48 | 0.17 |
| ARI+DARI concentration/ARI dose, d/L | 19.3 (11.1–30.7) | 15.1 (10.6–22.6) | −3.10 | 0.002 | 15.1 (11.7–23.2) | 14.2 (7.5–27.7) | 14.7 (11.1–18.1) | 15.9 (9.7–28.1) | 13.71 | 0.008 |
ARI, aripiprazole; CLZ, clozapine; DARI, dehydroaripiprazole; IQR, interquartile range; OLZ, olanzapine; QTP, quetiapine; RIP, risperidone; SD, standard deviation.