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. Author manuscript; available in PMC: 2021 Mar 30.
Published in final edited form as: Cell Rep. 2021 Feb 2;34(5):108707. doi: 10.1016/j.celrep.2021.108707

Figure 2. Recurrent coding alterations in RPA(–)G LUADs.

Figure 2.

(A) Overview of genomic alterations in 57 RPA(–)G LUADs. Genes significantly mutated (*) or significantly amplified/deleted in the RPA(–)G samples are listed.

(B and C) Example of KEAP1 (3 kbp length) (B) and (C) STK11 (8 kbp length) simple, homozygous deletion (CN = 0), resulting in loss of expression. The distribution of the KEAP1 or STK11 expression is plotted based on the full TCGA LUAD cohort.

(D) Expression comparison of samples with loss-of-function alterations in STK11 and (E) KEAP1 to other RPA(–)G LUAD samples. p values are calculated from Mann-Whitney U tests. Boxplots show median, interquartile range, and 1.5 times the interquartile range.

See also Figure S1.