Figure 4.

Mean Reduction in Severity of Vaginal Symptoms Across Interventions, Active vs. Placebo

X axis: Intervention vs. Placebo from left to right: vaginal estradiol tablet plus placebo gel vs. vaginal placebo tablet and vaginal placebo gel⁵; vaginal estradiol tablet vs. placebo tablet²¹; vaginal conjugated estrogen cream vs. placebo cream⁵⁹; vaginal soft gel vs. placebo gel²⁰; oral ospemifene vs. oral placebo tablet⁶⁰; vaginal dehydroepiandosterone suppository vs. vaginal placebo suppository⁶¹

Y axis: Reduction in vaginal symptom severity score (scale 0–3)