Table 2.
Gene Ontology analysis of the 1,093 differentially expressed genes between thin endometrium and adjacent normal endometrium.
| Term | Count | P-value | Genes | |
|---|---|---|---|---|
| GO:0007155 | Cell adhesion | 62 | 1.92E-10 | NRP2, MPZL3, CXCL12, PRKX, HMCN2, AZGP1, WISP2, WISP1, CTGF, COL12A1, AFDN, CEACAM1, EGFL6, ADGRE5, NECTIN4, GRHL2, CTNNA2, JUP, NCAM1, PGM5, CD36, LAMC3, VCAN, LAMC2, TGFB1I1, MFAP4, ADAM12, AOC3, OLFM4, ITGA11, PCDHGC3, ALCAM, LAMB3, SORBS1, ITGB8, COMP, MSLN, THBS1, ENTPD1, DPT, SPP1, HAPLN2, SELP, LPP, MCAM, EMILIN2, TINAGL1, COL4A6, LAMA2, ITGA9, CDH13, NME1-NME2, CDH16, DSG2, FREM2, CDON, ITGA7, NLGN4X, DSC2, PDZD2, OMG, MUC16 |
| GO:0030198 | Extracellular matrix organization | 31 | 4.19E-07 | MPZL3, ELF3, PDGFA, NPNT, ITGA11, CDH1, SOX9, SMOC2, LAMB3, HPSE, ITGB8, COMP, THBS1, SPP1, RXFP1, EGFL6, CCDC80, SPINT1, OLFML2A, COL4A6, COL4A5, LAMA2, ITGA9, BGN, LAMC3, KAZALD1, FBLN5, ITGA7, LAMC2, VCAN, MFAP5 |
| GO:0090190 | Positive regulation of branching involved in ureteric bud morphogenesis | 9 | 3.85E-06 | NOG, AGTR2, HOXB7, PAX8, SIX4, PAX2, GREM1, SOX9, WNT2B |
| GO:0045926 | Negative regulation of growth | 8 | 4.46E-05 | HIF1A, MT1M, MT2A, MT1H, MT1X, MT1G, MT1F, IGFBP5 |
| GO:0001525 | Angiogenesis | 29 | 4.63E-05 | NRP2, SAT1, CAV1, HTATIP2, PDGFA, CSPG4, FGF10, PRKX, NOV, TYMP, OVOL2, UNC5B, CTGF, XBP1, HS6ST1, SOX17, RAMP1, CEACAM1, SCG2, KLF5, MCAM, ECM1, HOXB3, HIF1A, CLIC4, ID1, PROK1, HIF3A, RBPJ |
| GO:0086073 | Bundle of His cell-Purkinje myocyte adhesion involved in cell communication | 5 | 1.30E-04 | JUP, DSG2, PKP2, DSC2, DSP |
| GO:0034329 | Cell junction assembly | 6 | 2.99E-04 | LIMS2, FERMT2, ILK, FLNC, GRHL2, FLNA |
| GO:0051145 | Smooth muscle cell differentiation | 6 | 4.63E-04 | MEF2C, WNT4, MYOCD, GATA6, HEY2, FGF10 |
| GO:0030336 | Negative regulation of cell migration | 15 | 7.39E-04 | PTPRJ, NOG, EPPK1, PLXNB3, DPYSL3, SLC9A3R1, TPM1, SLIT2, WNT4, PKP2, CLIC4, SFRP2, RRAS, STC1, IGFBP5 |
| GO:0001558 | Regulation of cell growth | 13 | 0.001477124 | NOV, PRKCQ, SGK1, WISP2, WISP1, CTGF, KAZALD1, FBLN5, FOXM1, RASGRP2, IGFBP6, CEACAM1, IGFBP5 |
| GO:0055015 | Ventricular cardiac muscle cell development | 5 | 0.001518037 | CCNB1, CDK1, HEY2, LMNA, FHL2 |
| GO:0090027 | Negative regulation of monocyte chemotaxis | 4 | 0.001571138 | NOV, MINOS1-NBL1, GREM1, SLIT2 |
| GO:0070830 | Bicellular tight junction assembly | 8 | 0.001582947 | OCLN, ACTN4, MARVELD2, CLDN3, MARVELD3, CRB3, ECT2, GRHL2 |
| GO:0050679 | Positive regulation of epithelial cell proliferation | 11 | 0.001599078 | NOG, OSR1, NME1-NME2, ID1, DLX6, DLX5, FGF10, ESRP2, PAX2, SOX9, IHH |
| GO:0002576 | Platelet degranulation | 15 | 0.001650782 | SELP, ACTN4, PDGFA, ACTN1, ECM1, TIMP3, FLNA, CTSW, ORM1, CD36, LEFTY2, SERPINA3, SERPINA1, THBS1, ORM2 |
| GO:0016055 | Wnt signaling pathway | 22 | 0.001694244 | NKD1, SPIN1, FERMT2, TLE2, FRZB, SLC9A3R1, APCDD1, WNT2B, CCNE1, RNF43, DKK3, WNT4, WISP1, RSPO1, CPE, DACT3, SFRP2, RSPO3, KREMEN1, RNF138, TGFB1I1, LRP4 |
| GO:0045216 | Cell–cell junction organization | 6 | 0.002445448 | OCLN, LIMS2, MARVELD2, MARVELD3, NLGN4X, CXADR |
| GO:0030308 | Cell growth negative regulation | 16 | 0.002889171 | PTPRJ, CRYAB, FHL1, FBP1, OSGIN2, FRZB, GREM1, SLIT2, RERG, NOV, AGTR2, MSX1, SFRP2, DACT3, CDKN2AIP, SOX17 |
| GO:0030514 | Negative regulation of BMP signal transduction pathway | 9 | 0.003034824 | RBPMS2, CAV1, NOG, CHRDL1, DKK1, MINOS1-NBL1, SFRP2, GREM1, TOB1 |