Table 3.
Kyoto Encyclopedia of Genes and Genomes pathway analysis of 1,093 differentially expressed genes between thin endometrium and adjacent normal endometrium.
| Term | Count | P-value | Genes | |
|---|---|---|---|---|
| hsa04270 | Vascular smooth muscle contraction | 22 | 2.32E-06 | KCNMA1, ACTA2, CALD1, MRVI1, PRKG1, ITPR3, KCNMB1, ITPR1, PRKCB, MYL9, ITPR2, PRKCQ, ACTG2, PLA2G4A, PLA2G2A, AVPR1A, PLA2G4F, CACNA1C, RAMP1, MYLK, ADRA1D, PPP1R14A |
| hsa04512 | Extracellular matrix–receptor interaction | 16 | 1.06E-04 | ITGA11, COL4A6, COL4A5, HMMR, LAMA2, ITGA9, LAMB3, SDC1, CD36, ITGB8, LAMC3, COMP, ITGA7, LAMC2, THBS1, SPP1 |
| hsa05410 | Hypertrophic cardiomyopathy | 15 | 1.14E-04 | ITGA9, ACE, ACTC1, DES, TNNC1, ITGB8, DMD, ITGA7, ITGA11, LMNA, CACNB2, TPM2, CACNA1C, TPM1, SGCA |
| hsa04510 | Focal adhesion | 26 | 2.73E-04 | CAV2, CAV1, ACTN4, PDGFA, MET, ITGA11, ACTN1, BIRC3, FLNC, COL4A6, FLNA, COL4A5, PRKCB, MYL9, LAMA2, ITGA9, LAMB3, LAMC3, ITGB8, COMP, ILK, ITGA7, LAMC2, THBS1, MYLK, SPP1 |
| hsa04530 | Tight junction | 14 | 0.001241795 | CLDN7, OCLN, CLDN4, ACTN4, CLDN3, CRB3, ACTN1, LLGL2, MYL9, CGN, MYH11, AFDN, MYH14, TJP3 |
| hsa04514 | Cell adhesion molecules | 18 | 0.002948225 | SELP, CLDN7, OCLN, CLDN4, CADM1, CLDN3, VTCN1, CD276, CDH1, HLA-DMB, ALCAM, NCAM1, ITGA9, SDC1, ITGB8, NLGN4X, VCAN, HLA-DOB |
| hsa04750 | Inflammatory mediator regulation of transient receptor potential channels | 14 | 0.003685506 | IL1R1, CYP2J2, CAMK2G, F2RL1, ITPR3, ITPR1, PRKCB, ITPR2, PRKCQ, PLA2G4A, MAPK13, PLA2G4F, CAMK2A, MAP2K6 |
| hsa04610 | Complement and coagulation cascades | 11 | 0.005535681 | C7, CD55, MASP1, C4A, C4B, C3, F3, SERPINA5, SERPINA1, CFI, C4BPA |
| hsa04670 | Leukocyte transendothelial migration | 14 | 0.013940458 | CLDN7, OCLN, CLDN4, ACTN4, CLDN3, ACTN1, CXCL12, PRKCB, MYL9, CTNNA2, EZR, CXCR4, MAPK13, AFDN |
| hsa04730 | Long-term depression | 9 | 0.020179859 | GNAZ, PLA2G4A, GRIA2, PLA2G4F, PRKG1, ITPR3, ITPR1, PRKCB, ITPR2 |
| hsa04911 | Insulin secretion | 11 | 0.022698704 | KCNMA1, CAMK2G, ADCYAP1R1, SLC2A1, KCNN2, ITPR3, CACNA1C, CAMK2A, SNAP25, KCNMB1, PRKCB |
| hsa04020 | Calcium signal transduction pathway | 18 | 0.02706823 | PTGER3, TNNC1, ERBB3, CAMK2G, ITPKB, PTGFR, ITPR3, ITPR1, PRKCB, ITPR2, GNAL, PLN, AVPR1A, CACNA1H, CACNA1C, CAMK2A, MYLK, ADRA1D |
| hsa00512 | Mucin type O-glycan biosynthesis | 6 | 0.029788794 | GALNT3, GCNT3, GALNT4, GALNT18, GALNT12, ST6GALNAC1 |
| hsa05150 | Staphylococcus aureus infection | 8 | 0.033164245 | SELP, MASP1, C4A, C4B, C3, CFI, HLA-DMB, HLA-DOB |
| hsa04720 | Long-term potentiation | 9 | 0.033723842 | GRIA2, RPS6KA1, CAMK2G, ITPR3, CACNA1C, CAMK2A, ITPR1, PRKCB, ITPR2 |
| hsa04912 | GnRH signal transduction pathway | 11 | 0.034509876 | PLA2G4A, MAPK13, CAMK2G, PLA2G4F, ITPR3, CACNA1C, CAMK2A, MAP2K6, ITPR1, PRKCB, ITPR2 |
| hsa04115 | p53 signal transduction pathway | 9 | 0.036464983 | CCNB1, CCNE1, CDK1, CCNB2, MDM4, SFN, THBS1, PERP, GTSE1 |
| hsa04520 | Adherens junction | 9 | 0.04891771 | PTPRJ, ACTN4, SORBS1, MET, ACTN1, CDH1, AFDN, NECTIN4, CTNNA2 |