Table 5.
Gene Oncology analysis of the identified targets of differentially expressed miRNAs between thin endometrium and adjacent normal endometrium.
| Term | Count | Fold enrichment | P-value | Targeted genes | |
|---|---|---|---|---|---|
| GO:0007264 | Small GTPase-mediated signal transduction | 22 | 2.37 | 3.79E-04 | RALGPS2, RAB3C, RAP2C, RAP1GDS1, RASGEF1B, RHOQ, ARF6, PLCE1, RAB43, ARF3, ARF4, ARHGAP1, YWHAQ, RAB5A, RAB14, RRAS, RHEB, RAB6B, RAP1B, RAB38, RIT2, RAB21 |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | 43 | 1.70 | 8.26E-04 | FOSL2, HELZ2, LMO4, EDN1, RHOQ, INO80, EGLN1, PAX3, ZEB1, ASH2L, PAX7, RARB, PPP3CA, MYC, GABPB2, SATB2, RARG, KLF12, EPAS1, MET, EOMES, IGF1, DLL1, DDX5, NCL, TET1, RBMX, BCL2L12, RNF222, FOXP1, PPARGC1B, MYCN, ASCL1, RPS6KA4, EBF3, ETS1, SP3, JUN, ARF4, ZFPM2, TFAP2D, NR5A2, BMPR1B |
| GO:0045765 | Regulation of angiogenesis | 6 | 7.24 | 1.02E-03 | ETS1, EFNA1, EGLN1, EMP2, VASH2, VASH1 |
| GO:0000045 | Autophagosome assembly | 8 | 4.69 | 1.28E-03 | GABARAPL2, GABARAPL1, ATG4B, MAP1LC3B, TRAPPC8, RB1CC1, WIPI2, TP53INP2 |
| GO:0000187 | Activation of MAPK activity | 8 | 4.00 | 3.32E-03 | MAP3K7, PLCE1, NTF3, EFNA1, IGF1, LPAR1, THBS1, FRS2 |
| GO:0030336 | Negative regulation of cell migration | 10 | 3.20 | 3.64E-03 | DLC1, RECK, TMEFF2, PTPRK, RAP2C, CLIC4, SULF1, RRAS, SRGAP1, SRGAP2 |
| GO:0051592 | Response to calcium ion | 6 | 5.13 | 5.29E-03 | CAV1, SLC25A13, ALG2, AHCYL1, PPP3CA, THBS1 |
| GO:0000422 | Mitophagy | 6 | 4.39 | 1.04E-02 | GABARAPL2, GABARAPL1, ATG4B, MAP1LC3B, RB1CC1, WIPI2 |
| GO:0051497 | Negative regulation of stress fiber assembly | 4 | 6.31 | 2.28E-02 | DLC1, TMEFF2, ARHGAP6, PPFIA1 |
| GO:0016601 | Rac protein signal transduction | 4 | 6.31 | 2.28E-02 | EPS8, WASF1, ELMO1, NCKAP1 |
| GO:0050679 | Positive regulation of epithelial cell proliferation | 6 | 3.51 | 2.61E-02 | WDR48, NOTCH1, FGF9, IGF1, MYC, FOXP1 |
| GO:0008277 | Modulation of G-protein coupled receptor protein signal transduction pathway | 4 | 5.86 | 2.80E-02 | PLCE1, GPR158, KCTD16, USP33 |
| GO:0060828 | Modulation of canonical Wnt signal transduction pathway | 4 | 5.47 | 3.37E-02 | AMER1, CCNY, CTNND2, CDK14 |
| GO:0035556 | Intracellular signal transduction | 22 | 1.60 | 3.52E-02 | ARHGEF3, SGK1, NUAK1, PREX1, DSTYK, SPSB4, ITSN1, PLCL2, RPS6KA4, SNRK, DGKE, PPP1R1C, STAC, GUCY1A3, DGKZ, RGS7, STK39, DCX, STK38L, PAG1, NET1, SHC4 |
| GO:0007205 | Protein kinase C-activating G-protein coupled receptor signaling pathway | 4 | 5.13 | 4.01E-02 | GRM5, DGKE, EDN1, DGKZ |
| GO:0008284 | Positive regulation of cell proliferation | 18 | 1.68 | 4.05E-02 | RARG, PDCD10, NTF3, PTH1R, IGF1, DLL1, PTGFR, TET1, TGFB2, CRKL, KRAS, ASH2L, HBEGF, RARB, MAB21L1, EMP2, CSF1R, SHC4 |