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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Hepatology. 2021 Mar;73(3):952–967. doi: 10.1002/hep.31321

Figure 2. 5-ASA administration protects mice from ALD.

Figure 2

C57BL/6 mice on a pair-fed or binge ethanol diet, with 5-ASA oral supplementation (50 mg/kg/day) or vehicle for 15 days (A-D) or for 28 days (E-G).

(A) H&E and Oil red O staining of liver tissue.

(B) Hepatic triglycerides.

(C) Serum levels of ALT and AST.

(D) Serum levels of lipids were analyzed by piccolo lipid pane plus.

(E) Fibrosis was evaluated by Sirius Red staining.

(F) Real-time PCR analysis of the expression of indicated genes in liver fibrosis.

(G) Serum markers of liver fibrosis, including hyaluronic acid and TIMP-1.

Data in all panels are presented as Mean ± SEM. n>15 * P<0.05; ** P<0.01