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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Hepatology. 2021 Mar;73(3):952–967. doi: 10.1002/hep.31321

Figure 6. Deficiency of SK1 attenuates the gut inflammation and accumulation of Th17 cells in ALD.

Figure 6

(A) H&E staining of small and large intestine.

(B) Alcian Blue staining and immunohistochemistry staining of mucin 2 in colonic tissue.

(C) Plasma levels of Dextran-FITC for gut permeability.

(D) Real-time PCR analysis of the expression of indicated genes in the colon (left) and IL-17A and Rorc mRNAs (right) in colonic LPLs.

(E) ELISA analysis of IL-17A or IL-23 in the supernatant of colonic LPLs.

(F) Intracellular staining of IL-17A+ and IFN-γ+ CD4+ T cells from gut LPL.

(G) Relative levels of S1P in the ileum of alcohol-fed mice.

(H) Immunofluorescence was used to evaluate the expression of pSTAT3 in the ileum.

Data in all panels are presented as Mean ± SEM. n=11 * P<0.05; ** P<0.01