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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Hepatology. 2021 Mar;73(3):952–967. doi: 10.1002/hep.31321

Figure 7. Deficiency of SK2 promotes liver injury in ALD.

Figure 7

WT or SK2−/− mice on a chronic-binge ethanol diet, with/without 5-ASA oral supplementation (50 mg/kg/day) or vehicle for 15 days.

(A) H&E staining and Oil red O staining of liver.

(B) The levels of serum ALT, AST and hepatic triglycerides.

(C) Frequencies of immature myeloid cells (CD11b+Gr-1+) in the liver.

(D) H&E staining of small and large intestine.

(E) Real-time PCR analysis of the levels of Muc2, Muc5a, IL-17A, Rorc and SK1 mRNA in the colon.

(F) Intracellular staining of IL-17A, IFN-γ, Foxp3 or RORγt in CD4+ T cells from colonic LPL.

Data in all panels are presented as Mean ± SEM. n=7 * P<0.05; ** P<0.01