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Frequency of Variations in the Selected Exons of BRCA1/2 Genes in Breast Cancer Patients as Detected by HRM Assay
| Non-Familial | Familial | p-value | |||
|---|---|---|---|---|---|
| N=50 (%) | N=30 (%) | ||||
| Variant | Variants | Variant | Variants | ||
| (1) | (2–4) | (1) | (2–4) | ||
| BRCA1 | |||||
| Exon 2 | 31(62) | 19(38) | 23(76.7) | 7(23.3) | 0.175 |
| Exon 19 | 30(60) | 20(40) | 18(60) | 12(40) | 1.000 |
| Exon 13 | 37(74) | 13 (26) | 15(50) | 15(50) | 0.029 |
| BRCA2 | |||||
| Exon 9 | 19(38) | 31(62) | 20(66.7) | 10(33.3) | 0.013 |
| Exon 11 F | 39(78) | 11(22) | 25(83.3) | 5(16.7) | 0.564 |
