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. 2021 Mar 26;13:2805–2810. doi: 10.2147/CMAR.S292730

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© 2021 Facchinetti et al.

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MRI evolution of brain metastases after fractionated stereotactic brain radiotherapy (A–C) and lorlatinib treatment (D). Three out of the five lesion treated with stereotactic radiotherapy are depicted (B), in the left thalamus (upper panel), left parietal lobe (middle panel) and left lateral ventricle (lower panel). In the upper panel, a contra-lateral sub-centimetric parietal lesion, visible in the first three MRI (A–C), is no more detectable after lorlatinib initiation (D). MRI sequences are 3D MP-RAGE (magnetization prepared – rapid gradient echo) after administration of chelate of gadolinium.