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. 2021 Mar 30;16(3):e0249284. doi: 10.1371/journal.pone.0249284

Table 4. The effect of DRD4 and SLC6A4 polymorphisms on depression adjusting for other covariates.

Model Covariate Odds ratio Confidence interval (95%) P
5-HTTLPR Genotype Education/ Illiterate - - -
Education/ Junior school 0.46 0.21–1.02 0.056
Education/ High school 0.27 0.12–0.59 0.001
Education/ College or over 0.27 0.11–0.63 0.003
Hypertension 1.83 0.96–3.5 0.066
Two dialysis session/week - - -
Three dialysis session/week 0.39 0.2–0.75 0.005
5-HTTLPR/ SS - - -
5-HTTLPR/ LS 0.74 0.35–1.55 0.426
  5-HTTLPR/ LL 1.13 0.59–2.16 0.722
5-HTTLPR Allele Education/ Illiterate - - -
Education/ Junior school 0.54 0.29–0.98 0.042
Education/ High school 0.29 0.16–0.53 <0.0001
Education/ College or over 0.29 0.15–0.54 <0.0001
Hypertension 1.8 1.12–2.89 0.016
Two dialysis session/week - - -
Three dialysis session/week 0.36 0.22–0.59 <0.0001
S allele - - -
  L allele 1.2 0.8–1.8 0.376
rs25531 Genotype Education/ Illiterate - - -
Education/ Junior school 0.48 0.22–1.06 0.068
Education/ High school 0.28 0.13–0.60 0.001
Education/ College or over 0.26 0.11–0.63 0.003
Two dialysis session/week - - -
Three dialysis session/week 0.38 0.19–0.73 0.004
rs25531 AG/GG - - -
  rs25531 AA 1.08 0.34–3.48 0.895
rs25531 Allele Education/ Illiterate - - -
Education/ Junior school 0.55 0.3–0.99 0.045
Education/ High school 0.29 0.16–0.53 <0.0001
Education/ College or over 0.29 0.15–0.55 <0.0001
Hypertension 1.81 1.12–2.9 0.015
Two dialysis session/week - - -
Three dialysis session/week 0.36 0.22–0.58 <0.0001
G allele - - -
  A allele 1.001 0.34–2.93 0.998
DRD4-Exon III Genotype Education/ Illiterate - - -
Education/ Junior school 0.48 0.22–1.07 0.072
Education/ High school 0.28 0.12–0.61 0.002
Education/ College or over 0.25 0.10–0.60 0.002
Two dialysis session/week - - -
Three dialysis session/week 0.42 0.22–0.82 0.011
DRD4/ (2,4) - - -
DRD4/ (2,2) 1.41 0.38–5.24 0.61
DRD4/ (4,4) 1.36 0.59–3.02 0.487
DRD4/ (4,5) 2.45 0.74–8.09 0.141
  DRD4/ (4,6) 2.46 0.74–8.19 0.144
DRD4-Exon III Allele Education/ Illiterate - - -
Education/ Junior school 0.54 0.29–0.98 0.042
Education/ High school 0.29 0.16–0.53 <0.0001
Education/ College or over 0.29 0.15–0.55 <0.0001
Hypertension 1.76 1.09–2.84 0.021
Two dialysis session/week - - -
Three dialysis session/week 0.37 0..23–0.60 <0.0001
DRD4/ 2 0.59 0.2–1.76 0.352
DRD4/ 4 0.63 0.24–1.61 0.333
DRD4/ 5 0.75 0.21–2.66 0.661
  DRD4/ 6 - - -