Table 2. Table Summarizing the User-Accessible MS Acquisition Scan Speeds, Advantages, and Disadvantages of the Three Instrumental Configurations Assessed in This Article When Coupled with Droplet Microfluidics.
| instrument type | DTIMS Q-TOF | TWIMS Q-TOF | Orbitrap (FT-MS) |
|---|---|---|---|
| instrument model | Agilent 6560 IM-Q-TOF | Waters SYNAPT G2Si | Thermo Fisher Q Exactive |
| fastest scan speed | 50 scans/s | 38 scans/s, 7700 scans/sa | 30 scans/s |
| coupling ease | difficult | easy | easy |
| advantages | grounded emitter | easy coupling | easy coupling |
| fastest user accessible scan/s | SONAR technology addition | ||
| disadvantages | stage controls not intuitive | voltage applied to emitter | voltage applied to emitter |
| interscan delay not variable | interscan delay | interscan delay not visible | |
| mounted chip not visible during usage | ESI source accessibility | isotopic resolution lost when increasing scan speed | |
| droplet frequency detectedb | 5 Hz | 11 Hz, 33 Hza | 6 Hz |
| droplet sizeb | 2.1 nL | 0.8 nL, 1.4 nLa | 0.8 nL |
a
User-accessible MS acquisition scan speed, droplet frequency, and size detected when SONAR technology is employed.
b
Droplet sizes and frequencies stated correspond to the conditions described in this article.