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. 2020 Jul 14;11(17):2728–2740. doi: 10.1021/acschemneuro.0c00363

Table 2. Permeability (Pe 10–6 cm s–1) in the PAMPA-BBB Assay for Compounds 4–7 with Their Predictive Penetration in the CNSa.

compound Pe (10–6 cm s–1)b prediction
4 2.5 ± 0.3 CNS +
5 4.8 ± 0.4 CNS +
6 4.5 ± 0.6 CNS +
7 1.7 ± 01 CNS +/CNS –
a

The PBS:EtOH (70:30) mixture was used as solvent.

b

Data are the mean ± SD of two independent experiments.