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. Author manuscript; available in PMC: 2021 Sep 15.
Published in final edited form as: Acta Biomater. 2020 Jul 8;114:407–420. doi: 10.1016/j.actbio.2020.07.006

Fig.2.

Fig.2

(A) The acid dissociation constant or pKa values for genistein, daidzein and glycitein are 6.51, 6.48 and 6.92, respectively, indicating that these isoflavones are easily deprotonated at physiological pH of 7.4, resulting in overall higher resonance stability and solubility in physiological pH (B) In vitro cumulative release of genistein in single and combined form fitted in Korsmeyer-Peppas model at DMEM (pH 7.4). A little increment in genistein release has been shown in the presence of other two isoflavones. (C) In vitro cumulative release of daidzein fitted in Korsmeyer-Peppas model showing increased in vitro release in the presence of a second drug in the system. (D) In vitro cumulative release of glycitein fitted in Korsmeyer-Peppas model showing lower cumulative release compared to other two isoflavones.