Table 2.

Changes from Baseline in MADRS, DSST, and PDQ-D Scores Over 6 Months

	n	Adjusted Mean Changes from Baseline (95% CI)
MADRS total score (lower values indicate less severe depressive symptoms)a
1 month	407	–8.41 (–9.20, –7.62)
2 months	395	–12.00 (–12.89, –11.10)
6 months	337	–16.05 (–16.99, –15.12)
DSST total score (higher values indicate better cognitive function)b
2 months	392	6.30 (5.10, 7.50)
6 months	334	8.15 (6.63, 9.68)
PDQ-D total score (lower values indicate better cognitive function)c
1 month	396	–6.78 (–7.77, –5.79)
2 months	384	–9.06 (–10.22, –7.90)
6 months	330	–11.99 (–13.37, –10.61)

Notes: ^aMean MADRS total score was 27.0 at baseline. ^bMean DSST total score was 72.4 at baseline. ^cMean PDQ-D total score was 32.2 at baseline.

Abbreviations: CI, confidence interval; DSST, Digital Symbol Substitution Test; MADRS, Montgomery–Åsberg Depression Rating Scale; PDQ-D, Patient Deficit Questionnaire–Depression.