A 55yr old male with Raynaud’s, sclerodactyly and antibodies to PmScl-75, Pm-Scl 100 and Ro-52 developed acute proximal myopathy with raised CpK. Initial response to 6 IV cyclophosphamide infusions (a) was not maintained with mycophenolate mofetil (MMF). Rituximab was started (b) alongside ongoing MMF. CT thorax identified patchy organising pneumonia.
The numbers represent Myositis Muscle Dysfucntion Scores (range 0–40 with higher numbers indicative of better strength).