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. 2021 Mar 30;9(5):293–303. doi: 10.1016/S2213-8587(21)00050-4

Table.

Characteristics of people with diabetes included in the cohort

DPP-4 inhibitors (n=479 555) GLP-1 receptor agonists (n=110 820) Insulin (n=350 960) Meglitinides (n=4440) Metformin (n=1 800 005) SGLT2 inhibitors (n=266 505) Sulfonylureas (n=561 290) Thiazolidinediones (n=60 085) α-glucosidase inhibitors (n=1665) Whole cohort (n=2 851 465)
Sex
Male 279 500 (58·3%) 57 250 (51·7%) 191 170 (54·5%) 2505 (56·4%) 1 044 920 (58·1%) 162 070 (60·8%) 339 715 (60·5%) 38 095 (63·4%) 945 (56·8%) 1 593 730 (55·9%)
Female 200 055 (41·7%) 53 570 (48·3%) 159 790 (45·5%) 1935 (43·6%) 755 085 (41·9%) 104 435 (39·2%) 221 575 (39·5%) 21 990 (36·6%) 720 (43·2%) 1 257 735 (44·1%)
Age, years
<40 7140 (1·5%) 3630 (3·3%) 8385 (2·4%) 55 (1·2%) 43 870 (2·4%) 8770 (3·3%) 9160 (1·6%) 720 (1·2%) 20 (1·2%) 77 260 (2·7%)
40–44 10 560 (2·2%) 4120 (3·7%) 7710 (2·2%) 90 (2·0%) 54 105 (3·0%) 11 345 (4·3%) 13 290 (2·4%) 1170 (1·9%) 30 (1·8%) 83 830 (2·9%)
45–49 21 505 (4·5%) 8265 (7·5%) 15 080 (4·3%) 180 (4·1%) 100 995 (5·6%) 22 955 (8·6%) 26 815 (4·8%) 2610 (4·3%) 50 (3·0%) 148 230 (5·2%)
50–54 36 535 (7·6%) 14 100 (12·7%) 26 215 (7·5%) 310 (7·0%) 162 155 (9·0%) 37 325 (14·0%) 45 660 (8·1%) 4740 (7·9%) 85 (5·1%) 231 885 (8·1%)
55–59 52 005 (10·8%) 18 825 (17·0%) 37 865 (10·8%) 480 (10·8%) 221 185 (12·3%) 48 770 (18·3%) 64 010 (11·4%) 7185 (12·0%) 140 (8·4%) 310 740 (10·9%)
60–64 61 805 (12·9%) 19 775 (17·8%) 46 435 (13·2%) 625 (14·1%) 250 810 (13·9%) 49 045 (18·4%) 75 980 (13·5%) 8860 (14·7%) 205 (12·3%) 353 870 (12·4%)
65–69 66 560 (13·9%) 17 460 (15·8%) 49 995 (14·2%) 635 (14·3%) 256 350 (14·2%) 40 240 (15·1%) 80 275 (14·3%) 9490 (15·8%) 235 (14·1%) 373 030 (13·1%)
70–74 73 860 (15·4%) 14 495 (13·1%) 54 185 (15·4%) 725 (16·3%) 265 195 (14·7%) 29 625 (11·1%) 86 025 (15·3%) 9850 (16·4%) 245 (14·7%) 410 275 (14·4%)
75–79 62 345 (13·0%) 6990 (6·3%) 44 720 (12·7%) 600 (13·5%) 203 020 (11·3%) 13 060 (4·9%) 69 440 (12·4%) 7445 (12·4%) 245 (14·7%) 341 090 (12·0%)
≥80 87 240 (18·2%) 3155 (2·8%) 60 380 (17·2%) 740 (16·7%) 242 325 (13·5%) 5360 (2·0%) 90 630 (16·1%) 8010 (13·3%) 415 (24·9%) 521 255 (18·3%)
Ethnicity
White 314 015 (65·5%) 84 525 (76·3%) 249 615 (71·1%) 2320 (52·3%) 1 160 760 (64·5%) 178 095 (66·8%) 357 320 (63·7%) 38 175 (63·5%) 940 (56·5%) 1 884 675 (66·1%)
Asian 75 275 (15·7%) 8800 (7·9%) 43 170 (12·3%) 1205 (27·1%) 288 450 (16·0%) 40 600 (15·2%) 96 625 (17·2%) 11 080 (18·4%) 390 (23·4%) 399 540 (14·0%)
Black 22 730 (4·7%) 3680 (3·3%) 16 380 (4·7%) 390 (8·8%) 85 750 (4·8%) 9650 (3·6%) 28 330 (5·0%) 2200 (3·7%) 125 (7·5%) 135 860 (4·8%)
Mixed 4800 (1·0%) 1010 (0·9%) 3500 (1·0%) 60 (1·4%) 19 700 (1·1%) 2875 (1·1%) 5945 (1·1%) 550 (0·9%) 20 (1·2%) 30 480 (1·1%)
Other 8780 (1·8%) 1835 (1·7%) 6065 (1·7%) 140 (3·2%) 31 855 (1·8%) 4965 (1·9%) 11 415 (2·0%) 1090 (1·8%) 50 (3·0%) 46 920 (1·6%)
Unknown 53 960 (11·3%) 10 965 (9·9%) 32 235 (9·2%) 330 (7·4%) 213 490 (11·9%) 30 320 (11·4%) 61 650 (11·0%) 6990 (11·6%) 135 (8·1%) 353 990 (12·4%)
Deprivation quintile
First (most deprived) 120 530 (25·1%) 30 145 (27·2%) 92 890 (26·5%) 1065 (24·0%) 459 675 (25·5%) 70 740 (26·5%) 143 840 (25·6%) 17 150 (28·5%) 405 (24·3%) 695 215 (24·4%)
Second 109 875 (22·9%) 24 940 (22·5%) 79 730 (22·7%) 1265 (28·5%) 410 585 (22·8%) 59 475 (22·3%) 130 730 (23·3%) 13 265 (22·1%) 450 (27·0%) 636 065 (22·3%)
Third 96 405 (20·1%) 21 820 (19·7%) 68 800 (19·6%) 775 (17·5%) 355 830 (19·8%) 52 145 (19·6%) 110 850 (19·7%) 11 425 (19·0%) 355 (21·3%) 570 380 (20·0%)
Fourth 83 805 (17·5%) 18 905 (17·1%) 59 990 (17·1%) 715 (16·1%) 311 140 (17·3%) 45 890 (17·2%) 95 460 (17·0%) 9850 (16·4%) 265 (15·9%) 510 220 (17·9%)
Fifth (least deprived) 68 685 (14·3%) 14 940 (13·5%) 49 380 (14·1%) 625 (14·1%) 261 875 (14·5%) 38 095 (14·3%) 80 145 (14·3%) 8360 (13·9%) 185 (11·1%) 438 095 (15·4%)
Unknown 255 (0·1%) 75 (0·1%) 175 (<0·1%) 0 900 (<0·1%) 160 (0·1%) 270 (<0·1%) 40 (0·1%) 5 (0·3%) 1485 (0·1%)
Region
London 85 280 (17·8%) 13 325 (12·0%) 51 195 (14·6%) 1830 (41·2%) 308 860 (17·2%) 37 050 (13·9%) 103 345 (18·4%) 6625 (11·0%) 505 (30·3%) 460 960 (16·2%)
South West 41 905 (8·7%) 11 795 (10·6%) 33 470 (9·5%) 180 (4·1%) 155 180 (8·6%) 25 455 (9·6%) 49 800 (8·9%) 5500 (9·2%) 100 (6·0%) 268 085 (9·4%)
South East 65 920 (13·7%) 18 535 (16·7%) 53 050 (15·1%) 475 (10·7%) 248 260 (13·8%) 41 490 (15·6%) 69 740 (12·4%) 9145 (15·2%) 195 (11·7%) 398 155 (14·0%)
Midlands 97 185 (20·3%) 21 970 (19·8%) 75 830 (21·6%) 715 (16·1%) 368 405 (20·5%) 53 240 (20·0%) 109 210 (19·5%) 11 430 (19·0%) 230 (13·8%) 581 070 (20·4%)
East of England 53 075 (11·1%) 12 215 (11·0%) 38 650 (11·0%) 385 (8·7%) 197 005 (10·9%) 28 005 (10·5%) 65 915 (11·7%) 6325 (10·5%) 245 (14·7%) 310 140 (10·9%)
North West 68 340 (14·3%) 15 175 (13·7%) 42 145 (12·0%) 560 (12·6%) 236 670 (13·1%) 39 105 (14·7%) 69 595 (12·4%) 9640 (16·0%) 195 (11·7%) 371 060 (13·0%)
North East and Yorkshire 67 600 (14·1%) 17 730 (16·0%) 56 445 (16·1%) 295 (6·6%) 284 725 (15·8%) 42 000 (15·8%) 93 410 (16·6%) 11 380 (18·9%) 185 (11·1%) 460 515 (16·2%)
Unknown 255 (0·1%) 75 (0·1%) 175 (<0·1%) 0 900 (<0·1%) 160 (0·1%) 270 (<0·1%) 40 (0·1%) 5 (0·3%) 1485 (0·1%)
Diabetes duration, years
<1 730 (0·2%) 85 (0·1%) 340 (0·1%) 5 (0·1%) 10 965 (0·6%) 460 (0·2%) 935 (0·2%) 25 (<0·1%) 5 (0·3%) 25 595 (0·9%)
1–2 19 525 (4·1%) 3005 (2·7%) 6740 (1·9%) 80 (1·8%) 180 825 (10·0%) 13 210 (5·0%) 18 075 (3·2%) 810 (1·3%) 35 (2·1%) 375 145 (13·2%)
3–4 35 195 (7·3%) 6100 (5·5%) 10 025 (2·9%) 130 (2·9%) 209 400 (11·6%) 23 390 (8·8%) 30 695 (5·5%) 1755 (2·9%) 40 (2·4%) 371 805 (13·0%)
5–9 123 830 (25·8%) 25 100 (22·6%) 42 700 (12·2%) 635 (14·3%) 502 950 (27·9%) 77 575 (29·1%) 128 480 (22·9%) 8955 (14·9%) 155 (9·3%) 786 040 (27·6%)
10–14 137 200 (28·6%) 33 270 (30·0%) 79 995 (22·8%) 1110 (25·0%) 436 870 (24·3%) 78 525 (29·5%) 170 575 (30·4%) 17 575 (29·3%) 305 (18·3%) 624 330 (21·9%)
15–19 104 120 (21·7%) 27 720 (25·0%) 102 560 (29·2%) 1380 (31·1%) 299 280 (16·6%) 51 050 (19·2%) 139 690 (24·9%) 19 825 (33·0%) 430 (25·8%) 424 060 (14·9%)
≥20 58 955 (12·3%) 15 535 (14·0%) 108 605 (30·9%) 1100 (24·8%) 159 715 (8·9%) 22 295 (8·4%) 72 835 (13·0%) 11 140 (18·5%) 700 (42·0%) 244 490 (8·6%)
Smoking status
Current smoker 56 030 (11·7%) 14 045 (12·7%) 43 315 (12·3%) 430 (9·7%) 235 240 (13·1%) 36 275 (13·6%) 70 620 (12·6%) 7145 (11·9%) 155 (9·3%) 364 855 (12·8%)
Ex-smoker 171 565 (35·8%) 43 220 (39·0%) 131 280 (37·4%) 1295 (29·2%) 626 170 (34·8%) 91 900 (34·5%) 195 115 (34·8%) 20 685 (34·4%) 540 (32·4%) 999 840 (35·1%)
Current non-smoker, history unknown 8540 (1·8%) 2105 (1·9%) 7065 (2·0%) 70 (1·6%) 29 825 (1·7%) 4365 (1·6%) 9070 (1·6%) 940 (1·6%) 25 (1·5%) 49 955 (1·8%)
Never smoked 243 180 (50·7%) 51 385 (46·4%) 169 015 (48·2%) 2645 (59·6%) 907 670 (50·4%) 133 830 (50·2%) 286 170 (51·0%) 31 280 (52·1%) 945 (56·8%) 1 434 475 (50·3%)
Unknown 245 (0·1%) 60 (0·1%) 285 (0·1%) 5 (0·1%) 1100 (0·1%) 135 (0·1%) 310 (0·1%) 35 (0·1%) 5 (0·3%) 2340 (0·1%)
BMI, kg/m2
<20 5620 (1·2%) 60 (0·1%) 4355 (1·2%) 90 (2·0%) 18 240 (1·0%) 900 (0·3%) 6405 (1·1%) 320 (0·5%) 25 (1·5%) 41 780 (1·5%)
20 to <25 66 450 (13·9%) 1780 (1·6%) 39 145 (11·2%) 930 (20·9%) 232 510 (12·9%) 21 170 (7·9%) 78 635 (14·0%) 5400 (9·0%) 310 (18·6%) 395 530 (13·9%)
25 to <30 160 740 (33·5%) 15 535 (14·0%) 98 855 (28·2%) 1525 (34·3%) 572 160 (31·8%) 75 925 (28·5%) 184 785 (32·9%) 16 600 (27·6%) 505 (30·3%) 899 635 (31·5%)
30 to <35 130 015 (27·1%) 34 570 (31·2%) 97 435 (27·8%) 1025 (23·1%) 487 320 (27·1%) 80 775 (30·3%) 150 640 (26·8%) 17 170 (28·6%) 390 (23·4%) 738 590 (25·9%)
35 to <40 59 790 (12·5%) 28 925 (26·1%) 55 040 (15·7%) 470 (10·6%) 245 045 (13·6%) 45 780 (17·2%) 71 010 (12·7%) 9910 (16·5%) 190 (11·4%) 364 950 (12·8%)
≥40 35 740 (7·5%) 26 360 (23·8%) 39 215 (11·2%) 230 (5·2%) 162 435 (9·0%) 32 205 (12·1%) 42 690 (7·6%) 7830 (13·0%) 135 (8·1%) 240 000 (8·4%)
Unknown 21 200 (4·4%) 3595 (3·2%) 16 915 (4·8%) 175 (3·9%) 82 290 (4·6%) 9745 (3·7%) 27 125 (4·8%) 2855 (4·8%) 105 (6·3%) 170 980 (6·0%)
HbA1c, mmol/mol (%)
<48 49 675 (10·4%) 10 500 (9·5%) 22 640 (6·5%) 500 (11·3%) 348 420 (19·4%) 15 110 (5·7%) 54 565 (9·7%) 8525 (14·2%) 260 (15·6%) 721 855 (25·3%)
48 to <54 (6·5% to <7·1%) 81 295 (17·0%) 13 305 (12·0%) 32 835 (9·4%) 690 (15·5%) 383 730 (21·3%) 32 745 (12·3%) 82 850 (14·8%) 11 805 (19·6%) 280 (16·8%) 591 760 (20·8%)
54 to <59 (7·1% to <7·5%) 78 775 (16·4%) 14 065 (12·7%) 39 490 (11·3%) 665 (15·0%) 274 865 (15·3%) 40 740 (15·3%) 84 115 (15·0%) 10 015 (16·7%) 265 (15·9%) 365 925 (12·8%)
59 to <75 (7·5% to <9·0%) 150 635 (31·4%) 35 950 (32·4%) 120 840 (34·4%) 1440 (32·4%) 423 835 (23·5%) 100 880 (37·9%) 177 575 (31·6%) 16 340 (27·2%) 445 (26·7%) 551 480 (19·3%)
75 to <86 (9·0% to <10·0%) 43 745 (9·1%) 14 180 (12·8%) 49 815 (14·2%) 400 (9·0%) 117 115 (6·5%) 31 835 (11·9%) 58 515 (10·4%) 4315 (7·2%) 125 (7·5%) 157 015 (5·5%)
≥86 43 860 (9·1%) 15 855 (14·3%) 58 470 (16·7%) 440 (9·9%) 122 515 (6·8%) 29 365 (11·0%) 63 930 (11·4%) 4810 (8·0%) 145 (8·7%) 174 815 (6·1%)
Unknown 31 575 (6·6%) 6965 (6·3%) 26 865 (7·7%) 300 (6·8%) 129 520 (7·2%) 15 830 (5·9%) 39 740 (7·1%) 4270 (7·1%) 140 (8·4%) 288 615 (10·1%)
eGFR, mL/min per 1·73 m2
≥90 167 690 (35·0%) 51 120 (46·1%) 110 645 (31·5%) 1615 (36·4%) 756 755 (42·0%) 146 240 (54·9%) 217 250 (38·7%) 21 570 (35·9%) 545 (32·7%) 1 065 540 (37·4%)
60 to <90 188 485 (39·3%) 43 055 (38·9%) 129 570 (36·9%) 1725 (38·9%) 788 790 (43·8%) 107 210 (40·2%) 226 340 (40·3%) 25 760 (42·9%) 675 (40·5%) 1 218 455 (42·7%)
45 to <60 61 320 (12·8%) 10 230 (9·2%) 49 395 (14·1%) 580 (13·1%) 177 890 (9·9%) 9710 (3·6%) 65 835 (11·7%) 7495 (12·5%) 240 (14·4%) 305 995 (10·7%)
30 to <45 41 320 (8·6%) 4535 (4·1%) 37 320 (10·6%) 340 (7·7%) 54 125 (3·0%) 1135 (0·4%) 35 240 (6·3%) 3610 (6·0%) 150 (9·0%) 144 705 (5·1%)
15 to <30 13 620 (2·8%) 880 (0·8%) 15 210 (4·3%) 100 (2·3%) 3275 (0·2%) 85 (<0·1%) 8920 (1·6%) 825 (1·4%) 40 (2·4%) 39 920 (1·4%)
<15 3045 (0·6%) 80 (0·1%) 4445 (1·3%) 35 (0·8%) 145 (<0·1%) 10 (<0·1%) 1360 (0·2%) 100 (0·2%) 5 (0·3%) 10 460 (0·4%)
Unknown 4080 (0·9%) 920 (0·8%) 4370 (1·2%) 50 (1·1%) 19 025 (1·1%) 2115 (0·8%) 6345 (1·1%) 725 (1·2%) 20 (1·2%) 66 390 (2·3%)
Systolic blood pressure, mm Hg
≤140 378 280 (78·9%) 88 240 (79·6%) 264 235 (75·3%) 3550 (80·0%) 1 416 115 (78·7%) 220 035 (82·6%) 436 215 (77·7%) 47 240 (78·6%) 1310 (78·7%) 2 163 325 (75·9%)
>140 74 180 (15·5%) 16 170 (14·6%) 66 250 (18·9%) 635 (14·3%) 268 680 (14·9%) 30 300 (11·4%) 88 410 (15·8%) 8735 (14·5%) 250 (15·0%) 449 595 (15·8%)
Unknown 27 100 (5·7%) 6410 (5·8%) 20 475 (5·8%) 255 (5·7%) 115 205 (6·4%) 16 175 (6·1%) 36 665 (6·5%) 4115 (6·8%) 105 (6·3%) 238 545 (8·4%)
Total serum cholesterol, mmol/L (mg/dL)
<5 (193 mg/dL) 360 345 (75·1%) 81 615 (73·6%) 251 225 (71·6%) 3385 (76·2%) 1 326 140 (73·7%) 192 115 (72·1%) 418 855 (74·6%) 45 750 (76·1%) 1290 (77·5%) 1 935 545 (67·9%)
≥5 (193 mg/dL) 67 360 (14·0%) 17 030 (15·4%) 53 815 (15·3%) 600 (13·5%) 274 535 (15·3%) 47 150 (17·7%) 77 290 (13·8%) 7645 (12·7%) 165 (9·9%) 508 140 (17·8%)
Unknown 51 850 (10·8%) 12 170 (11·0%) 45 920 (13·1%) 455 (10·2%) 199 330 (11·1%) 27 240 (10·2%) 65 140 (11·6%) 6690 (11·1%) 210 (12·6%) 407 785 (14·3%)
Disease history and medications
History of cardiovascular disease 131 585 (27·4%) 25 815 (23·3%) 124 635 (35·5%) 1105 (24·9%) 405 290 (22·5%) 48 605 (18·2%) 140 755 (25·1%) 9680 (16·1%) 480 (28·8%) 699 390 (24·5%)
Antihypertensive drugs 391 510 (81·6%) 92 110 (83·1%) 298 885 (85·2%) 3710 (83·6%) 1 403 145 (78·0%) 200 830 (75·4%) 453 100 (80·7%) 48 350 (80·5%) 1455 (87·4%) 2 185 685 (76·7%)
Statins 395 195 (82·4%) 93 010 (83·9%) 285 620 (81·4%) 3675 (82·8%) 1 444 545 (80·3%) 221 070 (83·0%) 459 485 (81·9%) 51 750 (86·1%) 1415 (85·0%) 2 099 315 (73·6%)
Glucose-lowering drugs
None 0 0 0 0 0 0 0 0 0 755 045 (26·5%)
One class 45 515 (9·5%) 4435 (4·0%) 88 210 (25·1%) 340 (7·7%) 842 515 (46·8%) 9380 (3·5%) 47 850 (8·5%) 2710 (4·5%) 140 (8·4%) 1 041 095 (36·5%)
Two classes 207 515 (43·3%) 30 805 (27·8%) 141 270 (40·3%) 1550 (34·9%) 557 100 (30·9%) 85 710 (32·2%) 232 145 (41·4%) 19 665 (32·7%) 290 (17·4%) 638 025 (22·4%)
Three classes or more 226 525 (47·2%) 75 580 (68·2%) 121 480 (34·6%) 2555 (57·5%) 400 390 (22·2%) 171 410 (64·3%) 281 295 (50·1%) 37 710 (62·8%) 1230 (73·9%) 417 300 (14·6%)
Outcome
Alive 467 325 (97·4%) 109 650 (98·9%) 338 180 (96·4%) 4345 (97·9%) 1 770 855 (98·4%) 264 850 (99·4%) 549 305 (97·9%) 59 175 (98·5%) 1620 (97·3%) 2 784 520 (97·7%)
Deaths in people with COVID-19* 2733 (0·6%) 279 (0·3%) 2825 (0·8%) 20 (0·5%) 6295 (0·3%) 458 (0·2%) 2628 (0·5%) 226 (0·4%) 15 (0·9%) 13 479 (0·5%)
Mortality rate (per 1000 person-years) 10·7 (10·3–11·1) 4·7 (4·1–5·2) 15·2 (14·7–15·8) 8·4 (4·7–12·2) 6·5 (6·4–6·7) 3·2 (2·9–3·5) 8·8 (8·4–9·1) 7·0 (6·1–7·9) 17·0 (8·4–25·5) 8·9 (8·7–9·0)
Deaths in people without COVID-19* 9499 (2·0%) 887 (0·8%) 9953 (2·8%) 76 (1·7%) 22 855 (1·3%) 1200 (0·5%) 9359 (1·7%) 684 (1·1%) 27 (1·6%) 53 469 (1·9%)
Mortality rate (per 1000 person-years) 37·3 (36·5–38·0) 14·9 (13·9–15·9) 53·7 (52·6–54·7) 32·1 (24·9–39·3) 23·8 (23·4–24·1) 8·4 (7·9–8·9) 31·3 (30·7–31·9) 21·3 (19·7–22·9) 30·5 (19·0–42·0) 35·2 (34·9–35·5)

Data are n (%), apart from mortality rates (95% CI). Data taken directly from the National Diabetes Audit are rounded to the nearest five people to protect confidentiality. eGFR=estimated glomerular filtration rate.

*

Death data from the Office for National Statistics and associated mortality rates are unrounded; whole-cohort data also include people who were prescribed none of the listed glucose-lowering drugs (4132 deaths with COVID-19).