Table 1.
Effect of Cch and NA on general cellular properties
| Part I | ||||||||
|---|---|---|---|---|---|---|---|---|
| 50 pA | 100 pA | 150 pA | 200 pA | 250 pA | 300 pA | 350 pA | ||
| nACSF | n = 47 | 1 ± 0 | 11 ± 2 | 21 ± 2 | 31 ± 2 | 37 ± 2 | 42 ± 2 | 46 ± 2 |
| Cch | 6 ± 2** | 23 ± 2*** | 35 ± 2*** | 41 ± 2*** | 46 ± 2*** | 49 ± 2*** | 53 ± 3** | |
| nACSF | n = 13 | 1 ± 1 | 7 ± 3 | 15 ± 3 | 22 ± 4 | 27 ± 5 | ||
| NA | 2 ± 1 | 12 ± 3* | 23 ± 4** | 31 ± 4** | 36 ± 4** | |||
| Part II | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| IR (MΩ) | TH (mV) | SAG | mAHP (mV) | ADP (mV) | ||||||
| n | n | n | n | n | ||||||
| nACSF | 48 | 105 ± 4 | 51 | −47.9 ± 0.6 | 48 | 0.166 ± 0.01 | 42 | −1.16 ± 0.11 | 42 | −0.27 ± 0.07 |
| Cch | 139 ± 6*** | −48.9 ± 0.7** | 0.151 ± 0.01 | −0.26 ± 0.14*** | 1.24 ± 0.15*** | |||||
| nACSF | 15 | 90 ± 6 | 9 | −46.4 ± 2.0 | 15 | 0.173 ± 0.01 | 9 | −1.47 ± 0.34 | 9 | −0.40 ± 0.25 |
| NA | 115 ± 8*** | −47.3 ± 1.8 | 0.115 ± 0.01** | −1.33 ± 0.27 | 0.23 ± 0.13* | |||||
Part I, Number of spikes elicited by 1-s current steps. Part II, Input resistance (IR), spike threshold (TH), sag ratio (SAG), medium AHP (mAHP), after depolarizing potential (ADP). Values correspond to mean ± SEM. Significance level: *p < 0.05, **p < 0.01, ***p < 0.001.