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. 2021 Mar 19;8(2):ENEURO.0378-20.2021. doi: 10.1523/ENEURO.0378-20.2021

Figure 3.

Figure 3.

Young mutant motoneurons have an aberrantly large input conductance. A, Plot of the motoneuron input conductance versus age in WT (blue squares) and mSOD1 (red diamonds) animals. The solid lines correspond to the linear regression lines with 95%CIs (shaded areas). WT slope = 0.018 μS/wk 95%CI[0.0061–0.029], r2 = 0.16 (p = 0.0035); SOD1 slope = −0.041 μS/wk 95%CI[−0.052–−0.03], r2 = 0.53 (p = 6.1e−10).) B, Breakdown of the difference in input conductance between WT and mSOD1 animals by age groups. P30–P60 WT: 0.42 ± 0.16 μS, N = 19 versus mSOD1: 0.72 ± 0.18 μS, N = 15; g = 1.73 95%CI[0.92–2.41]; t(32) = −5.06, ****p = 2.2e−05. P60–P90 WT: 0.46 ± 0.16 μS, N = 16 versus mSOD1: 0.42 ± 0.15 μS, N = 24; g = −0.28 95%CI[−0.96–0.37]; t(38) = 0.88, p = 0.39. P90–P120 WT: 0.60 ± 0.15 μS, N = 15 versus mSOD1: 0.33 ± 0.13 μS, N = 14; g = −1.85 95%CI[−2.57–−1.16]; t(27) = 5.16, ****p = 2.1e−05.