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. 2021 Mar 19;8(2):ENEURO.0378-20.2021. doi: 10.1523/ENEURO.0378-20.2021

Figure 4.

Figure 4.

The RMP of young adult mutant mice is hyperpolarized. A, Plot of the motoneuron RMP versus age in WT (blue squares) and mSOD1 (red diamonds) animals. The solid lines correspond to the linear regression lines with 95%CIs (shaded areas). WT: slope = −0.068 mV/wk 95%CI[−0.52–0.38], r2 = 0.0019 (p = 0.76). SOD1: slope = 0.81 mV/wk 95%CI[0.31–1.3], r2 = 0.18 (p = 0.0022). B, Breakdown of the difference in RMP between WT and mSOD1 animals by age groups. P30–P60 WT: −62.38 ± 5.52 mV, N = 19 versus mSOD1: −71.45 ± 8.78 mV, N = 15; g = −1.24 95%CI[−2.13–−0.23]; t(32) = 3.49, ***p = 0.002. P60–P90 WT: −60.98 ± 5.35 mV, N = 16 versus mSOD1: −66.18 ± 5.63 mV, N = 22; g = −0.92 95%CI[−1.54–−0.18]; t(36) = 2.89, **p = 0.0067. P90–P120 WT: −64.71 ± 7.42 mV, N = 15 versus mSOD1: −61.99 ± 5.43 mV, N = 13; g = 0.40 95%CI[−0.35–1.10]; t(26) = −1.12, p = 0.27.