Table 1.

Summary of the properties of the motoneurons, broken down by age range

	P30–P60			P60–P90			P90–P120
	WT (N = 19)	SOD1 (N = 15)	Hedges’ g	WT (N = 16)	SOD1 (N = 24)	Hedges’ g	WT (N = 15)	SOD1 (N = 14)	Hedges’ g
Input conductance	0.42 ± 0.16 μS [0.35–0.49]	0.72 ± 0.18 μS [0.64–0.82]	1.73 [0.93–2.40] (p = 2.2e −05****)	0.46 ± 0.16 μS [0.39–0.54]	0.42 ± 0.15 μS [0.36–0.48]	−0.28 [−0.96–0.39] (p = 0.39)	0.60 ± 0.15 μS [0.53–0.67]	0.33 ± 0.13 μS [0.26–0.39]	−1.85 [−2.57–−1.17] (p = 2.1e −05****)
PIC amplitude	2.30 ± 2.17 nA [1.52–3.45]	6.73 ± 3.28 nA [5.18–8.51]	1.59 [0.62–2.48] (p = 0.00016***)	2.47 ± 1.69 nA [1.81–3.51]	2.75 ± 2.40 nA [1.97–3.89]	0.12 [−0.53–0.67] (p = 0.67)	4.12 ± 3.69 nA [2.67–6.40]	1.90 ± 1.78 nA [1.24–3.19]	−0.74 [−1.27–0.00] (p = 0.05)
PIC amplitude (down ramp)	2.65 ± 2.60 nA [1.76–4.16]	5.55 ± 3.48 nA [4.01–7.45]	0.94 [0.15–1.70] (p = 0.013*)	2.29 ± 2.30 nA [1.52–4.01]	2.87 ± 2.22 nA [2.12–3.87]	0.25 [−0.50–0.82] (p = 0.44)	4.43 ± 3.10 nA [3.03–6.09]	2.25 ± 1.98 nA [1.48–3.56]	−0.81 [−1.49–−0.03] (p = 0.032*)
Current at transition SPR/PR	5.93 ± 3.24 nA [4.37–8.51]	8.01 ± 2.67 nA [6.54–9.24]	0.69 [−0.48–1.68] (p = 0.13)	6.28 ± 3.92 nA [4.32–9.67]	5.23 ± 3.30 nA [3.99–7.23]	−0.29 [−1.34–0.48] (p = 0.53)	5.90 ± 2.70 nA [4.24–7.38]	2.70 ± 2.34 nA [1.18–3.76]	−1.23 [−2.07–−0.35] (p = 0.0081**)
Recruitment current	4.73 ± 3.14 nA [3.50–6.23]	6.21 ± 2.51 nA [4.77–7.27]	0.50 [−0.25–1.26] (p = 0.14)	5.28 ± 2.64 nA [4.19–6.79]	4.53 ± 3.38 nA [3.35–6.35]	−0.24 [−0.94–0.43] (p = 0.46)	5.43 ± 3.07 nA [4.07–7.16]	2.19 ± 1.56 nA [1.59–3.32]	−1.26 [−1.96–−0.52] (p = 0.0017**)
Current at de- recruitment	5.92 ± 3.76 nA [4.38–7.65]	7.64 ± 3.31 nA [5.91–9.24]	0.47 [−0.24–1.19] (p = 0.17)	6.54 ± 4.07 nA [4.69–9.12]	5.01 ± 4.05 nA [3.54–7.04]	−0.37 [−1.16–0.33] (p = 0.31)	5.64 ± 2.95 nA [4.03–7.22]	2.59 ± 1.58 nA [1.93–3.64]	−1.26 [−2.23–−0.37] (p = 0.0056**)
Frequency at transition SPR/PR	54.30 ± 17.35 Hz [45.49–66.17]	57.90 ± 17.06 Hz [49.74–66.74]	0.20 [−0.65–1.04] (p = 0.62)	53.55 ± 13.32 Hz [44.57–62.21]	43.75 ± 13.55 Hz [36.99–49.60]	−0.70 [−1.52–0.09] (p = 0.11)	51.58 ± 15.41 Hz [41.70–59.94]	42.44 ± 11.34 Hz [36.74–48.89]	−0.67 [−1.58–0.23] (p = 0.13)
Normalized PIC amplitude (down ramp)	6.72 ± 5.77 nA/μS [4.50–9.57]	7.85 ± 4.85 nA/μS [5.49–10.58]	0.20 [−0.48–0.96] (p = 0.56)	5.05 ± 4.43 nA/μS [3.38–7.73]	6.81 ± 5.14 nA/μS [5.24–9.34]	0.35 [−0.35–0.89] (p = 0.26)	7.77 ± 5.24 nA/μS [5.46–10.56]	6.72 ± 4.91 nA/μS [4.77–9.82]	−0.20 [−0.92–0.60] (p = 0.58)
ΔI (current at de- recruitment− recruitment)	1.20 ± 1.20 nA [0.69–1.74]	1.45 ± 1.25 nA [0.89–2.17]	0.20 [−0.49–0.87] (p = 0.57)	1.47 ± 1.83 nA [0.57–2.52]	0.42 ± 1.10 nA [−0.01–0.94]	−0.72 [−1.57–0.05] (p = 0.093)	0.98 ± 1.32 nA [0.38–1.78]	0.39 ± 0.63 nA [0.05–0.71]	−0.55 [−1.28–0.27] (p = 0.18)
Voltage threshold (relative to RMP)	17.03 ± 6.37 mV [14.16–19.76]	18.09 ± 5.21 mV [15.10–20.44]	0.17 [−0.53–0.86] (p = 0.61)	15.59 ± 5.54 mV [13.26–18.55]	19.26 ± 6.29 mV [16.80–22.24]	0.60 [−0.13–1.26] (p = 0.072)	17.10 ± 5.54 mV [14.32–19.66]	13.79 ± 3.62 mV [12.09–15.77]	−0.67 [−1.44–0.15] (p = 0.071)
ΔF (frequency at de- recruitment− recruitment)	1.79 ± 13.96 Hz [−5.29–7.01]	3.77 ± 11.06 Hz [−1.51–9.55]	0.15 [−0.56–0.80] (p = 0.65)	6.53 ± 17.29 Hz [0.25–21.46]	1.93 ± 8.73 Hz [−1.51–6.16]	−0.36 [−1.12–0.37] (p = 0.4)	−0.85 ± 7.97 Hz [−4.64–4.12]	0.75 ± 7.97 Hz [−3.66–4.64]	0.19 [−0.66–1.04] (p = 0.62)
PIC peak voltage (relative to RMP)	18.32 ± 7.08 mV [15.26–21.42]	19.13 ± 8.15 mV [14.28–22.51]	0.10 [−0.61–0.82] (p = 0.76)	18.09 ± 7.71 mV [15.11–22.59]	21.18 ± 5.82 mV [19.14–23.99]	0.45 [−0.34–1.10] (p = 0.19)	16.37 ± 8.32 mV [12.41–20.31]	15.60 ± 5.86 mV [12.55–18.63]	−0.10 [−0.87–0.66] (p = 0.78)
F-I gain (PR, descending ramp)	19.21 ± 10.07 Hz/nA [15.19–29.17]	17.23 ± 5.15 Hz/nA [14.91–20.03]	−0.25 [−1.15–0.58] (p = 0.58)	33.93 ± 35.75 Hz/nA [18.24–75.19]	15.25 ± 8.95 Hz/nA [11.99–21.30]	−0.88 [−1.69–0.11] (p = 0.22)	15.15 ± 7.14 Hz/nA [11.73–20.87]	20.05 ± 11.30 Hz/nA [15.50–28.05]	0.48 [−0.48–1.07] (p = 0.23)
F-I gain (PR, ascending ramp)	9.30 ± 3.58 Hz/nA [7.08–11.31]	8.30 ± 3.37 Hz/nA [6.42–9.86]	−0.28 [−1.09–0.63] (p = 0.5)	12.18 ± 7.30 Hz/nA [8.81–19.47]	10.28 ± 6.43 Hz/nA [8.15–15.26]	−0.27 [−1.23–0.53] (p = 0.54)	8.01 ± 3.16 Hz/nA [6.33–10.08]	10.84 ± 9.13 Hz/nA [7.69–19.20]	0.38 [−0.41–0.94] (p = 0.31)
PIC onset voltage (relative to RMP)	4.36 ± 5.66 mV [1.69–6.68]	2.05 ± 5.38 mV [−1.02–4.23]	−0.41 [−1.05–0.28] (p = 0.23)	1.76 ± 5.75 mV [−0.85–4.65]	6.12 ± 5.54 mV [3.80–8.38]	0.76 [0.01–1.40] (p = 0.025*)	1.57 ± 5.10 mV [−0.86–4.11]	0.92 ± 5.94 mV [−1.76–4.48]	−0.11 [−0.93–0.64] (p = 0.76)
Resting membrane potential	−62.38 ± 5.52 mV [−64.71–−59.91]	−71.45 ± 8.78 mV [−75.13–−66.37]	−1.24 [−2.19–−0.28] (p = 0.002**)	−60.98 ± 5.35 mV [−63.81–−58.71]	−66.18 ± 5.63 mV [−68.56–−63.88]	−0.92 [−1.54–−0.19] (p = 0.0067**)	−64.71 ± 7.42 mV [−68.61–−61.39]	−61.99 ± 5.43 mV [−64.41–−58.61]	0.40 [−0.32–1.10] (p = 0.27)
Voltage threshold for spiking	−45.35 ± 5.48 mV [−47.79–−43.03]	−54.86 ± 5.15 mV [−57.21–−52.17]	−1.74 [−2.53–−0.84] (p = 1.9e −05****)	−45.39 ± 7.04 mV [−49.10–−42.26]	−47.53 ± 5.85 mV [−49.76–−44.73]	−0.33 [−1.04–0.38] (p = 0.34)	−47.61 ± 5.00 mV [−49.94–−45.17]	−48.20 ± 5.41 mV [−50.94–−45.31]	−0.11 [−0.85–0.63] (p = 0.77)
PIC peak voltage	−43.83 ± 4.79 mV [−45.74–−41.49]	−52.32 ± 4.20 mV [−54.10–−50.00]	−1.83 [−2.60–−1.03] (p = 4.8e −06****)	−42.89 ± 6.94 mV [−45.81–−39.26]	−44.88 ± 5.24 mV [−46.93–−42.88]	−0.33 [−0.97–0.33] (p = 0.34)	−48.34 ± 5.89 mV [−50.89–−45.11]	−46.24 ± 6.27 mV [−49.56–−43.26]	0.34 [−0.43–1.15] (p = 0.36)
PIC onset voltage	−58.03 ± 6.35 mV [−60.91–−55.34]	−69.41 ± 5.71 mV [−71.66–−66.01]	−1.83 [−2.69–−0.81] (p = 5.1e−06****)	−59.22 ± 4.88 mV [−61.96–−57.18]	−59.66 ± 6.39 mV [−61.98–−56.91]	−0.07 [−0.70–0.54] (p = 0.81)	−63.15 ± 6.31 mV [−65.99–−59.85]	−60.12 ± 7.25 mV [−63.92–−56.48]	0.43 [−0.35–1.17] (p = 0.24)
PIC end voltage	−58.67 ± 6.87 mV [−61.68–−55.65]	−71.37 ± 6.36 mV [−73.99–−67.60]	−1.86 [−2.69–−0.80] (p = 4.1e−06****)	−60.48 ± 4.90 mV [−63.57–−58.66]	−61.80 ± 7.27 mV [−64.75–−58.95]	−0.20 [−0.77–0.42] (p = 0.5)	−65.00 ± 5.70 mV [−67.79–−62.19]	−61.30 ± 8.12 mV [−65.34–−57.16]	0.52 [−0.28–1.27] (p = 0.17)
PIC peak voltage (down ramp)	−43.73 ± 4.89 mV [−45.62–−41.28]	−53.63 ± 4.90 mV [−55.76–−50.95]	−1.97 [−2.78–−1.17] (p = 2.1e−06****)	−42.49 ± 8.15 mV [−45.71–−37.94]	−45.85 ± 6.11 mV [−48.41–−43.56]	−0.47 [−1.08–0.16] (p = 0.17)	−48.14 ± 5.25 mV [−50.45–−45.05]	−45.98 ± 6.26 mV [−49.54–−43.13]	0.37 [−0.41–1.20] (p = 0.32)

The table shows the various properties that were measured in each motoneuron. The rows are sorted in descending order of effect size at P30–P60. WT and mSOD1 columns show mean values ± SD, with the 95%CI around the mean below. The Hedges’ g column shows the effect size and its 95%CI below.