Figure 8. Differences in DNA methylation between schizophrenia cases and controls are partially influenced by a subset of cases with treatment-resistant schizophrenia (TRS).

Forest plots from a meta-analysis of differences in DNA methylation at cg16322565 located in the NR1L2 gene on chromosome 3 between (A) schizophrenia patients and controls and (B) TRS patients prescribed clozapine and non-TRS prescribed other medications. TE: treatment effect (i.e., the mean difference between cases and controls); seTE: standard error of the treatment effect.

Figure 8—figure supplement 1. Forest plot of a site where DNA methylation is significantly associated with schizophrenia and within cases, with treatment-resistant schizophrenia.

TE: treatment effect (i.e., the mean difference between cases and controls); seTE: standard error of the treatment effect.

Figure 8—figure supplement 2. Forest plot of a site where DNA methylation is significantly associated with schizophrenia and within cases, with treatment-resistant schizophrenia but with an opposite directions of effect.

TE: treatment effect (i.e., the mean difference between cases and controls); seTE: standard error of the treatment effect.