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. Author manuscript; available in PMC: 2021 Mar 30.
Published in final edited form as: Am Soc Clin Oncol Educ Book. 2020 May;40:445–462. doi: 10.1200/EDBK_280729

FIGURE 4. Examples of Mesenchymal Neoplasms Showing Pan-TRK Expression by Immunohistochemistry.

FIGURE 4.

Infantile fibrosarcoma comprises monotonous population of spindle cells (A) with ETV6-NTRK3 rearrangement, detected by ETV6 break-apart fluorescence in situ hybridization (A, inset, arrows), and shows diffuse staining by pan-TRK immunohistochemistry (B). Lipofibromatosis-like neural tumor with spindled tumor cells lacking nuclear atypia containing wavy neural-like nuclei and eosinophilic cytoplasm with diffuse infiltration of adjacent fat (C) shows diffuse pan-TRK staining (D). Unclassified sarcoma of the endocervix comprising ovoid to spindled tumor cells with nuclear atypia scattered in a collagenous stroma with prominent hyalinized blood vessels (E) showing positive pan-TRK staining (F) suggestive of underlying NTRK rearrangement.