. Author manuscript; available in PMC: 2021 Mar 30.

Published in final edited form as: Am Soc Clin Oncol Educ Book. 2020 May;40:445–462. doi: 10.1200/EDBK_280729

TABLE 4.

Active Clinical Trials Using Modified Radiation Regimens in Preoperative or Postoperative Treatment of STS

NCT No.	Study Title	Patients	Radiotherapy Regimen
NCT02106312	Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcomas (DOREMY)	Adults with myxoid liposarcoma	2 Gy × 18 fractions = 36 Gy total (3.5 weeks)
NCT02701153	Phase II Study of 5-Day Hypofractionated Preoperative Radiation Therapy for Soft Tissue Sarcomas: Expansion Cohort	Adults with extremity and trunk STS	5–6 Gy × 5 fractions =30 Gy (1 week)
NCT02634710	Hypofractionated Pre-operative Radiation Therapy for Soft Tissue Sarcomas of the Extremity and Chest-wall	Adults with extremity and chest-wall STS	7 Gy × 5 fractions = 35 Gy (2 weeks)
NCT03819985	Shorter Course, Hypofractionated Pre-Surgery Radiation Therapy in Treating Patients With Localized, Resectable Soft Tissue Sarcoma of the Extremity of Superficial Trunk	Adults with extremity and trunk STS	2.85 Gy × 15 fractions = 42.75 Gy (3 weeks)
NCT02565498	Preoperative vs. Postoperative IMRT for Extremity/Truncal STS	Adults with extremity and trunk STS	2 Gy × 25 fractions = 50 Gy preoperatively or postoperatively (5 weeks)

Abbreviations: IMRT, intensity-modulated radiation therapy; STS, soft-tissue sarcoma.