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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Methods Enzymol. 2020 Nov 18;647:173–208. doi: 10.1016/bs.mie.2020.10.002

Figure 2-. Schematics of sensors utilizing ER/K linkers.

Figure 2-

Generalized schematics of published sensor proteins that incorporate the ER/K linker. ER/K linkers have successfully been used to generate sensors employed to investigate cellular interactions involving GPCRs, kinases, motors, and second messenger signaling. ER/K-linked sensors are constructed so that the domains can be interchanged with relative ease during molecular cloning using restriction sites between protein elements (top right). Select citations for each sensor (superscript numbering) are also listed (bottom right).