Table 1.
Baseline demographics and characteristics (FAS; N = 80)
| Parameter | SFOH (N = 65) | CaAc (N = 15) |
|---|---|---|
| Mean ± SD age at randomization, years | 12.1 ± 4.10 | 12.3 ± 3.96 |
| 2–< 6 years, n (%) | 6 (9.2) | 1 (6.7) |
| 6–< 12 years, n (%) | 17 (26.2) | 4 (26.7) |
| 12–≤ 18 years, n (%) | 42 (64.6) | 10 (66.7) |
| Male, n (%) | 31 (47.7) | 5 (33.3) |
| Mean ± SD body weight, kg | 42.1 ± 18.1 | 37.4 ± 19.2 |
| Etiology of CKD, n (%) | ||
| Congenital anomalies of the kidney and urinary tract | 19 (29.2) | 3 (20.0) |
| Glomerulonephritis | 10 (15.4) | 4 (26.7) |
| Hypodysplasia and reflux | 2 (3.1) | 2 (13.3) |
| Obstructive uropathy | 8 (12.3) | 1 (6.7) |
| Polycystic kidney disease | 3 (4.6) | 0 |
| Other | 23 (35.4) | 5 (33.3) |
| CKD stage, n (%) | ||
| 4 | 13 (20.0) | 1 (6.7) |
| 5 | 52 (80.0) | 14 (93.3) |
| Dialysis modality, n (%) | ||
| Hemodialysis | 45 (69.2) | 9 (60.0) |
| Peritoneal dialysis | 5 (7.7) | 5 (33.3) |
| None | 15 (23.1) | 1 (6.7) |
| Phosphate binder-naïve, n (%) | ||
| Yes | 18 (27.7) | 3 (20.0) |
| No | 47 (72.3) | 12 (80.0) |
| Washout period needed, n (%) | ||
|
n (missing) Yes |
47 (18) 7 (14.9) |
12 (3) 4 (33.3) |
| No | 40 (85.1) | 8 (66.7) |
| Mean (SD) baseline serum phosphorus, mg/dLa | 6.41 (1.62) | 6.67 (2.07) |
CaAc, calcium acetate; CKD, chronic kidney disease; FAS, full analysis set; SD, standard deviation; SFOH, sucroferric oxyhydroxide
aSerum phosphorus data are from central laboratory