Fig. 1.

Structural features of TAZ. a Genome structure of human TAZ. Five different transcript variants of TAZ (NM_015472.6, NM_001168278.3, NM_001168280.3, NM_001348362.2, and XM_017006122.1) are produced from human chromosome 3 (GRCh38.p13) and are encoded as the same human TAZ comprising of 400 amino acids. b Mouse chromosome 3 (GRCm39) comprises of TAZ exons and introns. Two different transcript variants (NM_00168281.1 and NM_00168281.1) are generated and encoded as two isoforms of TAZ; isoform 1, 452 aa and isoform 2, 395 aa. c Amino acid alignment between human and mouse TAZ. Mouse TAZ isoform 1 contains additional 57 aa at the N-terminus and has no similarity with human TAZ. d Schematic structure of human and mouse TAZ proteins. The percent identity for a given sequence is presented. TB, TEAD-binding domain; WW, W-containing domain; CC, coiled-coil domain; and (p) sites, phosphorylation sites