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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Clin Trials. 2021 Jan 10;18(2):237–244. doi: 10.1177/1740774520982315

Table 2.

Means and Paired Mean Differences in RAQ Scores Over Time

Baseline
(N=119)
Mean
(95%CI)		 Week 26
(N=111)
Mean
(95%CI)		 Week 52
(N=95)
Mean
(95%CI)		 Wk26 – BL
(N=119)
PMD
(95%CI)		 Wk52 – BL
(N=119)
PMD
(95%CI)
Participant RAQ 30.6 (29.7 to 31.4) 30.9 (30.0 to 31.5) 30.2 (29.2 to 31.0) 0.1 (−0.07 to 1.1) −0.4 (−1.4 to 0.4)
Adjusted Participant RAQ 31.2 (28.5 to 33.3) 33.5 (31.3 to 35.8) 32.3 (30.0 to 34.8) 0.1 (−1.0 to 1.2) −0.4 (−1.5 to 0.7)
Study Partner RAQ 30.4 (29.4 to 31.1) 31.1 (30.4 to 31.7) 31.2 (30.2 to 31.8) 0.6 (−0.1 to 1.6) −0.2 (−0.9 to 0.6)
Adjusted Study Partner RAQ 29.9 (26.6 to 32.2) 30.9 (29.2 to 32.7) 32.6 (30.5 to 34.9) 0.6 (−0.4 to 1.7) 0.7 (−0.4 to 1.8)
PMD (95%CI) PMD (95%CI) PMD (95%CI) DID (95%CI) DID (95%CI)
Study Participant – Study Partner RAQ 0.3 (−0.6 to 1.2) −0.3 (−1.2 to 0.6) −1.0 (−2.2 to 0.2) 0.5 (−0.3 to 1.6) 0.6 (−0.4 to 1.5)
Adjusted Study 1.3 (−1.8 to 4.4) 2.6 (0.2 to 5.3) −0.3 (−3.2 to 2.4) −0.5 (−1.8 to 0.7) −1.3 (−2.7 to 0.1)
Participant – Study Partner RAQ

Note. Fixed effects analysis. Analysis assumes zero change for individuals with missing data follow up data. Adjusted analyses statistically control for study arm assignment. DID = Difference-in-difference; PMD = Paired Mean Difference; 95%CI= 95% bias corrected and accelerated confidence interval based on 1000 bootstrap samples.