Table 3.
Participant and Study Partner Correlates of Baseline RAQ Scores
| Trivariate Model (N=119) Mean Difference (95%CI) |
Full Multivariable Model (N=119) Mean Difference (95%CI) |
|
|---|---|---|
| Study Participant | ||
| Age, years | −0.07 (−0.31 to 0.04) | |
| Female vs. Male | 0.37 (−1.41 to 2.59) | |
| Education (years) | 0.11 (−0.48 to 0.64) | |
| ADCS ADL scorea | 1.71 (−0.33 to 3.66) | 1.66 (−0.75 to 3.81) |
| ADAS-cog scorea,b | 0.95 (−1.27 to 2.61) | |
| NPI scorea,b | 1.64 (−0.65 to 4.20) | 1.51 (−1.03 to 4.37) |
| APOE genotypec | ||
| Heterozygote | −1.66 (−3.86 to 0.38) | −1.97 (−4.33 to 0.03) |
| Homozygote | 0.65 (−1.77 to 2.57) | |
| Study Partner | ||
| Resides with participantd | 2.05* (0.27 to 4.45) | 0.91 (−2.77 to 3.65) |
| Hours per week with participant | 0.01 (−0.0 to 0.03) | 0.02 (−0.01 to 0.05) |
| Female vs malee | −0.0 (−0.05 to 0.06) | |
| Spouse vs non-spouse | 1.33 (−0.60 to 3.41) | −0.34 (−3.40 to 2.57) |
| Participant characteristics | ||
| Age, years | −0.03 (−0.24 to 0.15) | |
| Female vs. male | −0.29 (−1.70 to 1.89) | |
| ADCS ADL scorea | 1.68 (−0.14 to 3.25) | 0.79 (−1.07 to 2.98) |
| ADAS-cog scorea,b | 1.66* (0.10 to 3.52) | 0.82 (−1.05 to 2.69) |
| NPI scorea,b | 3.81*** (1.77 to 6.09) | 3.71 (1.17 to 6.26)** |
Note. Adjusted analyses statistically control for study arm allocation and participant clustering within study site. Alpha to carry forward from trivariate analyses to full multivariable model was P<0.20. APOE = Apolipoprotein E; ADAS = Alzheimer's Disease Assessment Scale; ADCS = Alzheimer's Disease Cooperative Study; ADL = Activities of Daily Living.
a
Dichotomized at median value
b
Predicting lower value.
c
Noncarrier is reference category.
d
Does not reside with study patient is reference category. Resides with study patient includes one person who lives half-time with patient.
e
Sex/gender is unknown for 5 study partners.
*
≤0.05
**
≤0.01
***
≤0.001