Appendix 2:

Cut points for baseline RAQ scores for each study outcome and time point

	Baseline	Week 26	Week 52
Study Patient
Compliant based on pill check	ICS	28.5	27.5
Study completion vs dropout	ICS	ICS	25.5
Enrollment in PK studiesa	28.5	28.5	28.5
Study Partner
Compliant based on pill check	ICS	NA	34.5
Study completion vs dropout	ICS	ICS	28.5
Enrollment in PK studiesa	NA	34.5	32.5
Study Patient – Study Partner (PMD)
Compliant based on pill check	ICS	0.5	1.5
Study Completion vs dropout	ICS	ICS	−6.5
Enrollment in PK studiesa	−1.5	−1.5	−1.5

Note. ICS = insufficient cell size; PK = pharmacokinetic.

^aSubsample of participants at study sites that recruited at least one participant into PK studies.